摘要
Abstract
Objective:To investigate the clinical effect of Nd∶YAP laser combined with periodontal basic treatment in patients with stage Ⅲ B/C grade periodontitis.Method:A total of 120 patients with stage Ⅲ B/C grade periodontitis treated in Beijing Huairou Hospital from January 2022 to June 2023 were selected,and they were divided into study group and control group by random number table method,with 60 cases in each group.The control group was given periodontal basic treatment,and the study group was given Nd∶YAP laser combined with periodontal basic treatment.The clinical efficacy,periodontal status,levels of inflammatory factors in gingival crevicular fluid,and structural indexes of subgingival flora were compared between the two groups.Result:The total effective rate of the study group was 98.75%,which was higher than 87.80%of the control group,and the difference was statistically significant(P<0.05).At 6 weeks after treatment,the bleeding on probing(BOP),probing depth(PD),clinical attachment loss(CAL),hypoxia inducible factor-1α(HIF-1α),intercellular adhesion molecule-1(ICAM-1)and interleukin-6(IL-6)in both groups were lower than those at baseline,and which in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).At 6 weeks after treatment,when Shannon indexes in the two groups were higher than that baseline,Simpson indexes were lower than that baseline,but the Shannon index in the study group was lower than that in the control group,and Simpson index was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Nd∶YAP laser combined with periodontal basic treatment can improve the clinical effect,improve the periodontal condition,regulate the level of inflammatory factors in gingival crevicular fluid and control the growth of periodontal pathogens in patients with stage Ⅲ B/C grade periodontitis.关键词
牙周炎/Nd∶YAP激光/牙周基础治疗/临床效果/龈沟液炎症因子Key words
Periodontitis/Nd∶YAP laser/Periodontal basic therapy/Clinical effects/Inflammatory factors in gingival crevicular fluid
