中外医学研究2024，Vol.22Issue(10)：11-15,5.DOI:10.14033/j.cnki.cfmr.2024.10.003
持续气道正压通气联合特拉唑嗪与缬沙坦对阻塞性睡眠呼吸暂停低通气综合征合并高血压患者的影响
Effects of Continuous Positive Airway Pressure Combined with Terazosin and Valsartan on Patients with Obstructive Sleep Apnea Hypopnea Syndrome Complicated with Hypertension
摘要
Abstract
Objective:To investigate the effects of continuous positive airway pressure(CPAP)combined with Terazosin and Valsartan on patients with obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with hypertension.Method:A total of 80 patients with OSAHS complicated with hypertension who were treated in the First Hospital of Putian from January 2021 to January 2022 were selected.They were divide int the control group and the study group according random number table method,with 40 cases in each group.Both groups were given conventional treatment,the control group was treated with Terazosin combined with Valsartan,and the study group was treated with CPAP based on the control group.The clinical efficacy,blood pressure level,inflammatory factors,oxidative stress,sleep quality,quality of life and efficacy satisfaction were compared between the two groups.Result:The total clinical effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood pressure,inflammatory factors and oxidative stress between the two groups(P>0.05).After treatment,systolic blood pressure(SBP),diastolic blood pressure(DBP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and serum malondialdehyde(MDA)in the study group were lower than those in the control group,and superoxide dismutase(SOD)was higher than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in Pittsburgh sleep quality index(PSQI)score and sleep apnea quality of life index(SAQLI)score between the two groups(P>0.05).After treatment,PSQI score of the study group was lower than that of the control group,and SAQLI score was higher than that of the control group,the differences were statistically significant(P<0.05).The therapeutic satisfaction of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:CPAP combined with Terazosin and Valsartan can improve the sleep quality and quality of life of patients with OSAHS complicated hypertension,reduce the inflammatory response and blood pressure levels of patients,regulate the oxidative stress level of patients,and improve the efficacy and satisfaction.关键词
持续气道正压通气/特拉唑嗪/缬沙坦/阻塞性睡眠呼吸暂停低通气综合征/睡眠质量Key words
Continuous positive airway pressure/Terazosin/Valsartan/Obstructive sleep apnea hypopnea syndrome/Quality of sleep引用本文复制引用
郑勋伯,陈志斌,陈晨腾..持续气道正压通气联合特拉唑嗪与缬沙坦对阻塞性睡眠呼吸暂停低通气综合征合并高血压患者的影响[J].中外医学研究,2024,22(10):11-15,5.基金项目
莆田学院校内科研项目(2021058) （2021058）
