补肺舒喘汤联合孟鲁司特钠片治疗肺气虚型咳嗽变异性哮喘的效果OA
Effect of Bufei Shuchuan Decoction Combined with Montelukast Sodium Tablets in the Treatment of Cough-variant Asthma of Lung Qi Deficiency Type
目的:探讨补肺舒喘汤联合孟鲁司特钠片治疗肺气虚型咳嗽变异性哮喘的效果.方法:选取 2022 年 1 月—2023 年 12 月北京市昌平区沙河医院收治的 96 例肺气虚型咳嗽变异性哮喘患者.根据随机数表法将其分为对照组与中医组,各 48 例.对照组给予孟鲁司特钠片,中医组在对照组基础上给予补肺舒喘汤治疗.比较两组临床疗效,治疗前后炎症因子、肺功能及不良反应.结果:治疗后,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)、红细胞沉降率(ESR)水平均低于治疗前,中医组IL-6、CRP、PCT及ESR水平均低于对照组,差异有统计学意义(P<0.05).治疗后,两组用力肺活量(FVC)、第 1 秒用力呼气容积(FEV1)、最大呼气流速峰值(PEF)均高于治疗前,中医组FVC、FEV1、PEF均高于对照组,差异有统计学意义(P<0.05).中医组临床总有效率高于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:补肺舒喘汤联合孟鲁司特钠片治疗肺气虚型咳嗽变异性哮喘,能够控制其炎症因子水平,改善肺功能,提高疗效,且不会增加不良反应.
Objective:To explore the effect of Bufei Shuchuan Decoction combined with Montelukast Sodium Tablets in the treatment of cough-variant asthma of lung Qi deficiency type.Method:A total of 96 patients with cough-variant asthma with lung Qi deficiency type treated in Shahe Hospital,Changping District,Beijing from January 2022 to December 2023 were selected.According to the method of random number table,they were divided into control group and traditional Chinese medicine group,48 cases in each group.The control group was given Montelukast Sodium Tablets,and the traditional Chinese medicine group was given Bufei Shuchuan Decoction on the basis of the control group.The clinical efficacy,inflammatory factors,lung function before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)and erythrocyte sedimentation rate(ESR)in both groups were lower than those before treatment,and the levels of IL-6,CRP,PCT and ESR in traditional Chinese medicine group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and peak maximum expiratory flow rate(PEF)in both groups were higher than those before treatment,and FVC,FEV1 and PEF were higher than those in control group,the differences were statistically significant(P<0.05).The total clinical effective rate of the traditional Chinese medicine group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Bufei Shuchuan Decoction combined with Montelukast Sodium Tablets can control the level of inflammatory factors,improve the lung function,and enhance the curative effect without increasing the side effects of lung Qi deficiency type cough-variant asthma.
吴金娟
北京市昌平区沙河医院 北京 102206
补肺舒喘汤孟鲁司特钠片肺气虚型咳嗽变异性哮喘疗效
Bufei Shuchuan DecoctionMontelukast Sodium TabletsLung Qi deficiency typeCough variant asthmaCurative effect
《中外医学研究》 2024 (010)
19-23 / 5
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