中外医学研究2024，Vol.22Issue(12)：64-67,4.DOI:10.14033/j.cnki.cfmr.2024.12.016
异烟肼雾化吸入治疗初治菌阳空洞型肺结核的临床研究
Clinical Study of Atomized Inhalation of Isoniazid in the Treatment of Primary Treatment Germ Positive Cavity-type Pulmonary Tuberculosis
摘要
Abstract
Objective:To investigate the effect of atomized inhalation of Isoniazid in the treatment of primary treatment germ positive cavity-type pulmonary tuberculosis.Method:Forty-five patients with primary treatment germ positive cavity-type pulmonary tuberculosis admitted to Pingnan People's Hospital from July 2021 to December 2022 were selected as the study objects.They were divided into conventional group(n=23)and atomized group(n=22)according to random number table method.The conventional group was given conventional anti-tuberculosis treatment,and the atomizing group was given Isoniazid atomizing inhalation therapy on the basis of the control group.Bacteria turning negative condition,cavity closure condition after 2 months and 6 months of treatment and adverse reactions were compared between the two groups.Result:After 2 months of treatment,the sputum conversion negative rate of atomization group was higher than that of conventional group,and the average time of sputum conversion negative was earlier than that of control group,the differences were statistically significant(P<0.05).The cavity closure rate after 2 months and 6 months in the atomization group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Isoniazid nebulization assisted conventional anti-tuberculosis therapy has a higher sputum negative conversion rate,faster sputum negative conversion,better lesion absorption,and better treatment effect with good safety.关键词
异烟肼/雾化吸入/空洞型肺结核/空洞闭合情况Key words
Isoniazid/Atomizing inhalation/Cavitary pulmonary tuberculosis/Cavity closure condition引用本文复制引用
李少辉,谢沛栖,覃诗勇..异烟肼雾化吸入治疗初治菌阳空洞型肺结核的临床研究[J].中外医学研究,2024,22(12):64-67,4.基金项目
贵港市自筹经费科研项目(贵科攻2000011) （贵科攻2000011）
