中外医学研究2024，Vol.22Issue(12)：74-78,5.DOI:10.14033/j.cnki.cfmr.2024.12.019
血清胱抑素C、N末端B型利钠肽原对慢性肾脏病合并心力衰竭的预测价值
Predictive Value of Serum Cystatin C and N-terminal Pro-B-type Natriuretic Peptide in Chronic Kidney Disease Combined with Heart Failure
王斌 1曾晖 1李光1
作者信息
- 1. 武汉市第七医院 湖北 武汉 430061
- 折叠
摘要
Abstract
Objective:To investigate the efficacy of serum cystatin C(Cys C)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in predicting chronic kidney disease(CKD)combined with heart failure(HF).Method:A retrospective study was conducted on the medical records of 70 CKD patients who visited the Seventh Hospital of Wuhan from June 2020 to June 2022.They were divided into occurrence group(18 cases,with HF)and non occurrence group(52 casese,without HF)based on whether HF occurred within one year after the patients'visit.The baseline data and laboratory indexes were compared between the two groups.The relationship between Cys C,NT-proBNP and CKD combined with HF was analyzed.The value of serum Cys C and NT-proBNP in predicting CKD complicated with HF was discussed by receiver operating characteristic(ROC)curve.Result:The proportion of CKD stages 3 and 4,Cys C and NT-proBNP levels in the occurrence group were significantly higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Point two-column correlation analysis showed that Cys C and NT-proBNP were positively correlated with CKD combined with HF(P<0.05).The area under the curve(AUC)values of Cys C and NT-proBNP alone and combined in predicting CKD combined with HF were 0.828,0.868 and 0.904,respectively,and the combined prediction value was the highest.Conclusion:Serum Cys C and NT-proBNP have higher predictive value for CKD combined with HF,and the higher the values,the higher the likelihood of CKD combined with HF.关键词
慢性肾脏病/心力衰竭/胱抑素C/N末端B型利钠肽原Key words
Chronic kidney disease/Heart failure/Cystatin C/N-terminal pro-B-type natriuretic peptide引用本文复制引用
王斌,曾晖,李光..血清胱抑素C、N末端B型利钠肽原对慢性肾脏病合并心力衰竭的预测价值[J].中外医学研究,2024,22(12):74-78,5.
