中华临床免疫和变态反应杂志2024，Vol.18Issue(2)：169-173,5.DOI:10.3969∕j.issn.1673-8705.2024.02.010
cGAS-STING信号通路在系统性红斑狼疮中的研究进展
Research progress of cGAS-STING signaling pathway in systemic lupus erythematosus
摘要
Abstract
The cGAS-STING signaling pathway plays a crucial role in the regulation of immune response,which can sense the presence of DNA in the cytoplasm and activate a series of downstream molecules,leading to the release of inflammatory cytokines such as typeⅠinterferon,and ultimately participating in and regulating the occurrence of immune response.The pathogenesis of SLE is complex,immune dysfunction and cytokines such as typeⅠinterferon participate in the development of SLE.This paper will review the research progress of cGAS-STING signaling pathway in SLE,in order to provide a new direction for its diagnosis and targeted therapy.关键词
cGAS-STING信号通路/系统性红斑狼疮/干扰素/免疫反应/靶向治疗Key words
cGAS-STING signaling pathway/systemic lupus erythematosus/interferon/immune re-sponse/target therapy引用本文复制引用
苏雅珍,李瑞娇,刘凡铖,张莉芸..cGAS-STING信号通路在系统性红斑狼疮中的研究进展[J].中华临床免疫和变态反应杂志,2024,18(2):169-173,5.基金项目
山西省基础研究计划自然科学研究面上项目(202103021224342) （202103021224342）
山西省医学重点科研项目(2021XM01) （2021XM01）
山西省免疫与风湿性疾病临床诊疗技术创新中心科研项目(LYZX-202305) （LYZX-202305）
山西省高等学校科技创新项目(2023L075) Basic Research Project of Shanxi Science and Technology Project(202103021224342) （2023L075）
Key Research and Development(R&D)Projects of Shanxi Province(2021XM01) （R&D）
Shanxi Province Clinical Re-search Center for Dermatologic and Immunologic Diseases(LYZX-202305) （LYZX-202305）
Shanxi Province Higher Educa-tion Science and Technology Innovation Project(2023L075) （2023L075）
