中华临床免疫和变态反应杂志2024，Vol.18Issue(2)：174-180,7.DOI:10.3969∕j.issn.1673-8705.2024.02.011
肥大细胞在特应性皮炎发病中的作用及相关治疗进展
Role of mast cells in the pathogenesis of atopic dermatitis and related treatment progress
摘要
Abstract
The pathophysiology of atopic dermatitis(AD)is complex and multifactorial.Multiple cells are involved in.Mast cells which are mainly located in skin and mucous membrane have been recognized as ma-jor effective cells in pathogenesis of allergic diseases.However,the role of mast cells in AD is not fully under-stood.Results of recent studies have shown the role of the'IgE-FcεRI-histamine'axis and the'MrgprB2/X2-tryptase'axis in the pathogenesis of AD.Mast cells can also release a variety of type 2 inflammatory cytokines to further promote the immune imbalance in AD.Research progress of mast cells in the pathogenesis of AD and the novel targeted therapeutic strategies for treatment were reviewed in this article.关键词
肥大细胞/特应性皮炎/高亲和力IgE受体/mas相关G蛋白偶联受体Key words
mast cell/atopic dermatitis/high-affinity IgE receptor/mas-related G protein-coupled receptor引用本文复制引用
陈玉迪,刘琬,杨敏,常建民..肥大细胞在特应性皮炎发病中的作用及相关治疗进展[J].中华临床免疫和变态反应杂志,2024,18(2):174-180,7.基金项目
中央高水平医院临床科研业务费(BJ-2022-126) National High Level Hospital Clinical Research Funding(BJ-2022-126) （BJ-2022-126）
