神经药理学报2024，Vol.14Issue(1)：18-22,5.DOI:10.3969/j.issn.2095-1396.2024.01.003
保妇康栓联合重组人干扰素α-2b治疗高危HPV感染的疗效和安全性观察
Observation on the Efficacy and Safety of Baofukang Suppository Combined with Recombinant Human Interferon α-2b in the Treatment of High-Risk HPV Infection
陈莹 1尤继文 2林艳 2陈云香3
作者信息
- 1. 福建省福安市妇幼保健院孕产保健科,福安,355000,中国
- 2. 福建省福安市妇幼保健院妇保科,福安,355000,中国
- 3. 福建省福安市医院中医科,福安,355000,中国
- 折叠
摘要
Abstract
Objective:To investigate the efficacy and safety of Baofukang suppository on the basis of recombinant human interferon α-2b in the treatment of high-risk human papillomavirus(HR-HPV)infection.Methods:80 HR-HPV patients were randomly divided into 2 groups.The control group(40 cases)was treated with recombinant human interferon α-2b vaginal effervescent capsule.The observation group(40 cases)was treated with Baofukang suppository on the basis of recombinant human interferon α-2b vaginal effervescent capsule.Both groups were treated for 3 months.The treatment effects of the two groups were compared.The duration of abnormal secretions,HPV viral load,TCT test results and cervical inflammation scores of the two groups were recorded,and the adverse reactions were observed.Results:Compared with the control group(75.00%),the total effective rate of the observation group(95.00%)was higher(P<0.05).The duration of abnormal secretions in the observation group was(14.47±3.15)d,comparing with the control group(20.12±3.89)d,shows significantly shorter(P<0.05).After treatment,the normal rate of TCT in the two groups was significantly higher than that before treatment(P<0.05),and the normal rate of TCT in the observation group was higher than that in the control group(P<0.05).After treatment,the HPV viral load in the observation group decreased comparing with the control group(P<0.05),and the cervical inflammation score decreased(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Baofukang suppository based on recombinant human interferon α-2b vaginal effervescent capsule is effective and safe in the treatment of HR-HPV infection.关键词
人乳头瘤病毒/重组人干扰素α-2b/保妇康栓/疗效Key words
human papillomavirus/recombinant human interferon α-2b/baofukang suppository/curative effect分类
医药卫生引用本文复制引用
陈莹,尤继文,林艳,陈云香..保妇康栓联合重组人干扰素α-2b治疗高危HPV感染的疗效和安全性观察[J].神经药理学报,2024,14(1):18-22,5.
