神经药理学报2024，Vol.14Issue(1)：57-64,8.DOI:10.3969/j.issn.2095-1396.2024.01.010
线粒体动力学调控肿瘤相关机制的研究进展
Advances in the Regulation of Mitochondrial Dynamics on Tumor Cells
宁康浩 1闫聚瀚 1闫晓冬 2李佳程 1李向东2
作者信息
- 1. 河北北方学院研究生学院,张家口,075000,中国
- 2. 河北北方学院附属第一医院泌尿外科,张家口,075000,中国
- 折叠
摘要
Abstract
Mitochondrial dynamics is the dynamic balance process in which mitochondria continuously divide and fuse under physiological or stimulating conditions,thereby regulating the distribution,quantity,size and shape of mitochondria in the cell.In cells,the regulation of mitochondrial dynamics is closely related to the functions of mitochondria,which include providing energy,regulating calcium homeostasis,participating in programmed cell death,cell signal transduction,and cell metabolism.In cancer,mitochondrial dynamic regulation is closely related to the proliferation,migration,treatment and drug resistance of tumor cells.Therefore,mitochondrial dynamic regulation has become a research hotspot in the field of cancer,and has shown great potential in tumor therapy.In this review,we review the key features that mediate mitochondrial dynamic regulation,and discuss the mechanisms involved in tumorigenesis and development and its potential in tumor therapy.关键词
线粒体动力学/线粒体融合/线粒体分裂/肿瘤Key words
mitochondrial dynamics/mitochondrial fusion/mitochondria division/tumor分类
医药卫生引用本文复制引用
宁康浩,闫聚瀚,闫晓冬,李佳程,李向东..线粒体动力学调控肿瘤相关机制的研究进展[J].神经药理学报,2024,14(1):57-64,8.
