北华大学学报（自然科学版）2024，Vol.25Issue(4)：477-481,5.DOI:10.11713/j.issn.1009-4822.2024.04.010
Cr和NGAL预测老年重度烧伤患者早期急性肾损伤的应用价值
Application Value of Serum Creatinine and Neutrophil Gelatinase-associated Lipocalin in Predicting Early Acute Kidney Injury in Elderly Patients with Severe Burn
摘要
Abstract
Objective Exploring the application value of creatinine(Cr)and neutrophil gelatinase-associated lipid transport protein(NGAL)in predicting early acute kidney injury in elderly patients with severe burns.Method 53 elderly burn patients were selected,all with burn areas greater than 20%.Patients were divided into AKI group(28 cases)and non-AKI group(25 cases)based on whether AKI occurred.Within 48 hours after admission,whole blood NGAL and Cr measurements were collected every 6 hours.The determination of serum Cr was carried out by using the oxidase method.The determination of NGAL was carried out by using commercially available enzyme-linked immunosorbent assay.And use the receiver operating curve(ROC)to calculate the area under the curve(AUC),compare the diagnostic ability of indicators.Results The burn area of patients in AKI group was significantly higher than that of non-AKI group patients(P<0.01);There was no statistically significant difference in age,mean arterial pressure,central venous pressure,and urine output of patients between the two groups(P>0.05).The serum NGAL levels of patients in AKI group were significantly higher than those in non-AKI group at 6 hours(P<0.01);The serum NGAL and Cr levels in AKI group were significantly higher than those of non-AKI group at 12 hours,24 hours(P<0.01,P<0.05).The results of constructing ROC curves show that the cut-off values of serum Cr and blood NGAL are 86.08 μmol/L and 125.75 ng/mL have high predictive value for AKI in burn patients,with higher sensitivity and positive predictive value of blood NGAL in predicting AKI in burn patients.Conclusion Plasma NGAL levels measured within 48 hours of admission can predict AKI in elderly patients with severe burns,and serum NGAL can show higher predictive value than serum Cr.关键词
重度烧伤/老年人/急性肾损伤/肌酐/中性粒细胞明胶酶相关脂质运载蛋白/预测价值Key words
severe burns/elderly people/acute kidney injury/creatinine/neutrophil gelatinase associated lipid transport protein/predictive value分类
医药卫生引用本文复制引用
杨佳伟,田野,蒲丹,任天水,刘金宝..Cr和NGAL预测老年重度烧伤患者早期急性肾损伤的应用价值[J].北华大学学报（自然科学版）,2024,25(4):477-481,5.基金项目
吉林省科技发展计划项目(20210201033LC). （20210201033LC）
