大学化学2024，Vol.39Issue(4)：322-328,7.DOI:10.3866/PKU.DXHX202309095
Aldol缩合-水解"一锅"法制备反式肉桂酸
Preparation of Trans-Cinnamic Acid via"One-Pot"Protocol of Aldol Condensation-Hydrolysis Reaction:Recommending an Improved Organic Synthesis Experiment
摘要
Abstract
Cinnamic acid is an important intermediate in organic synthesis and a valuable raw material in the fine chemicals industry,with a wide range of applications across various fields.The preparation of cinnamic acid is a significant component in undergraduate organic chemistry experiments.Traditionally,it is achieved through the classic Perkin reaction,using benzaldehyde and acetic anhydride as starting materials and employing potassium acetate/potassium carbonate as catalysts.This article proposes a novel approach,namely the Aldol condensation-hydrolysis method,for the synthesis of trans-cinnamic acid.In this method,benzaldehyde,ethyl acetate,and potassium tert-butoxide are used as reactants,and the reaction proceeds through a"one-pot"process involving reflux,distillation,alkali hydrolysis,distillation again,and acidification,ultimately yielding pure trans-cinnamic acid.This method offers numerous advantages,including the use of inexpensive raw materials and reagents,low quantities required,simple equipment setup,low energy consumption,easy operation,high yield,short reaction time,and minimal environmental pollution.Therefore,it is highly recommended for undergraduate experimental teaching.Furthermore,this method not only helps students acquire a comprehensive understanding of fundamental theoretical knowledge and experimental skills but also encourages them to think innovatively in terms of convenient and efficient synthesis of organic compounds.Additionally,it fosters awareness of energy conservation and environmental protection,contributing to the development of well-rounded individuals.关键词
反式肉桂酸/苯甲醛/乙酸乙酯/叔丁醇钾/"一锅"合成Key words
Trans-Cinnamic acid/Benzaldehyde/Ethyl acetate/Potassium tert-butoxide/"One-pot"synthesis分类
社会科学引用本文复制引用
常煜琨,黄昊秦,王宝雷..Aldol缩合-水解"一锅"法制备反式肉桂酸[J].大学化学,2024,39(4):322-328,7.基金项目
国家自然科学基金(22077070) （22077070）
