MCM4作为增殖信号影响肺腺癌的免疫浸润和预后OACSTPCD
MCM4 as a proliferation signal affects immune infiltration and prognosis in lung
目的:微小染色体维持蛋白4(minichromosome maintenance protein 4,MCM4)是DNA复制起始和延伸阶段的调控因子.本研究旨在探究肺腺癌(lung adenocarcinoma,LUAD)中MCM4 的表达与肿瘤微环境(tumor microenvironment,TME)中免疫细胞和分子的相关性,以及MCM4预测患者免疫治疗敏感性和预后的能力.方法:从癌症基因组图谱(The Cancer Genome Atla…查看全部>>
Objective:Minichromosome maintenance protein 4(MCM4)is a regulator involved in the initiation and elongation stages of DNA replication.This study aims to investigate the correlation between MCM4 expression and immune cells and molecules in the tumor microenvironment(TME)of lung adenocarcinoma(LUAD),and the ability of MCM4 to predict patient sensitivity to immunotherapy and prognosis. Methods:Transcriptome data and clinical data of LUAD patients were download…查看全部>>
金燕;许斌;宋启斌
武汉大学人民医院肿瘤中心,武汉 430060武汉大学人民医院肿瘤中心,武汉 430060武汉大学人民医院肿瘤中心,武汉 430060
微小染色体维持蛋白4肺腺癌增殖免疫抑制预后
minichromosome maintenance protein 4lung adenocarcinomaproliferationimmunosuppressionprognosis
《临床与病理杂志》 2024 (2)
169-182,14
评论