构建胃癌中CD8+T细胞相关预后模型并筛选治疗药物OACSTPCD
Construction of a CD8+T cell-related prognostic model in gastric cancer and therapeutic drug screening
目的:胃癌是高度异质性的恶性肿瘤,其病死率高,患者就诊时多已处于晚期且预后差.CD8+T细胞可识别和消灭肿瘤细胞,对癌症的进展有重要影响.本研究旨在构建CD8+T细胞浸润相关预后模型,为胃癌患者预后评估提供新的生物标志物及其药物治疗提供客观依据.方法:从癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中下载371例胃癌样本的数据为训练集.从基因表达综合(Gene Expression Omnibus,GEO)数据库…查看全部>>
Objective:Gastric cancer is a highly heterogeneous malignant tumor with a high mortality rate.Patients often present at advanced stages with poor prognosis.CD8+T cells play a crucial role in recognizing and eliminating tumor cells,significantly influencing cancer progression.This study aims to construct a prognostic model related to CD8+T cell infiltration to provide new biomarkers for prognostic assessment and objective evidence for drug therapy in gastric …查看全部>>
张立;唐旭鹏;申娟宁;李宁
山西医科大学第一临床医学院,太原 030001山西医科大学第一临床医学院,太原 030001山西医科大学第一临床医学院,太原 030001山西医科大学第一医院病理科,太原 030001
胃癌CD8+T细胞预后模型药物敏感性
gastric cancerCD8+T cellsprognostic modeldrug sensitivity
《临床与病理杂志》 2024 (2)
183-198,16
山西省基础研究计划(自由探索类)项目(202303021221210).This work was supported by the Basic Research Project of Shanxi Province(Free exploration class),China(202303021221210).
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