临床与病理杂志2024，Vol.44Issue(2)：199-206,8.DOI:10.11817/j.issn.2095-6959.2024.230436
IL-13Rα2在胃癌及癌前病变中的表达及其临床意义
Expression of IL-13Rα2 in gastric cancer and precancerous lesions and its clinical significance
摘要
Abstract
Objective:The long-term inflammatory microenvironment promotes atrophy,intestinal metaplasia,dysplasia of the gastric epithelium,and the occurrence of gastric cancer,but the mechanism is still unclear.This study aims to detect the expression of interleukin-13 receptor α2(IL-13Rα2)in gastric and precancerous lesions and explore its clinical significance. Methods:A total of 210 biopsies were divided into 5 groups:a chronic non-atrophic gastritis group(CNAG group,n=30),a chronic atrophic gastritis with intestinal metaplasia group(CAG/IM group,n=50),a low-grade dysplasia group(LGD group,n=30),a high-grade dysplasia group(HGD group,n=30),and a gastric cancer group(GC group,n=70).The expression of IL-13Rα2 in these groups was detected using the immunohistochemical EnVision two-step method.Additionally,the expression of IL-13Rα2 in 120 cases from radical gastric cancer surgery was analyzed to examine the relationship between IL-13Rα2 expression and the clinicopathological features of gastric cancer. Results:The positive rates of IL-13Rα2 expression in the CNAG,CAG/IM,LGD,HGD,and GC groups were 3.3%,42%,13.3%,6.7%,and 84.3%,respectively.Compared to the CNAG group,the positive expression rate of IL-13Ra2 in the CAG/IM group increased significantly(P<0.05).Compared to the CAG/IM group,the positive rates in the LGD and HGD groups decreased(both P<0.05),whereas it increased significantly in the GC group(P<0.001).In radical specimens,the positive expression rate of IL-13Rα2 in gastric cancer tissues was significantly higher than that in adjacent non-tumor tissues(P<0.001).Clinicopathological analysis showed that the positive expression of IL-13Rα2 in gastric cancer was related to Lauren classification,which was higher in intestinal type than that in diffuse,solid,and mixed types(all P<0.001).There was no significant correlation between IL-13Rα2 expression and the patient's age,gender,Helicobacter pylori infection status,clinical staging,or lymph node metastasis(all P>0.05). Conclusion:IL-13Rα2 shows weak positive expression in gastric intestinal metaplasia and strong positive expression in gastric cancer.IL-13Rα2 is highly expressed specifically in intestinal-type gastric cancer and holds promise as a new therapeutic target for gastric cancer.关键词
白细胞介素13受体α2/胃癌/癌前病变/免疫组织化学Key words
interleukin-13 receptor α2/gastric cancer/precancerous lesions/immunohistochemistry引用本文复制引用
倪慕兰,李燕维,陈永东,王宇航..IL-13Rα2在胃癌及癌前病变中的表达及其临床意义[J].临床与病理杂志,2024,44(2):199-206,8.基金项目
福建中医药大学校管科研课题临床专项(XB2022053).This work was supported by the School Management Project on Clinical Research of Fujian University of Traditional Chinese Medicine,China(XB2022053). （XB2022053）
