不同肠型孤独症患儿的肠道菌群和发育特征OACSTPCD
Characteristics of gut microbiota and development in children with different enterotypes of autism
目的:并发胃肠道症状的孤独症谱系障碍(autism spectrum disorder,ASD)患儿常伴随肠道菌群异常,肠道菌群及其代谢物可能通过迷走神经、免疫、代谢途径参与ASD发病.本研究旨在探讨不同肠型ASD患儿的肠道菌群特征、发育特征和胃肠道症状,进一步探讨肠道菌群和生长、发育的联系.方法:选取2023年1月至2023年6月在上海市第六人民医院进行康复训练的13例ASD患儿.采用宏基因组学检测患儿粪便样本的肠道菌群,并进行肠型分析.采用香…查看全部>>
Objective:Children with autism spectrum disorder(ASD)who exhibit concurrent gastrointestinal symptoms often have abnormal intestinal microbiota.The microbiota and their metabolites may participate in the pathogenesis of ASD through vagus nerve,immune,and metabolic pathways.This study aims to explore the characteristics of the intestinal microbiota,developmental characteristics,and gastrointestinal symptoms in children with ASD of different intestinal types,a…查看全部>>
韦金盈;刘田雨;张凤;陈嘉怡;陈娟娟;袁延涵;张金萍
上海海洋大学食品学院,上海 201306上海海洋大学食品学院,上海 201306上海海洋大学食品学院,上海 201306上海市第六人民医院儿科,上海 201306上海市第六人民医院儿科,上海 201306上海市第六人民医院儿科,上海 201306上海市第六人民医院儿科,上海 201306
孤独症谱系障碍胃肠微生物组宏基因组学格里菲斯发育评估
autism spectrum disordergastrointestinal microbiomemetagenomicsGriffiths developmental assessment
《临床与病理杂志》 2024 (2)
230-241,12
上海市第六人民医院横向科研项目(XCT0273003).This work was supported by the Safety and Efficacy of Fecal Microbiota Transplantation in Children with Autism Spectrum Disorder,China(XCT0273003).
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