临床与病理杂志2024，Vol.44Issue(2)：295-306,12.DOI:10.11817/j.issn.2095-6959.2024.240119
铁稳态、铁死亡与心血管疾病
Iron homeostasis,ferroptosis,and cardiovascular diseases
吴楠 1杨涛 1胡玉原 2程心萌 3刘振豪 1王学宁1
作者信息
- 1. 山西医科大学第三医院,山西白求恩医院,山西医学科学院,同济山西医院心脏大血管外科,太原 030032
- 2. 潍坊市人民医院心血管外科,山东 潍坊 261000
- 3. 山西省心血管病医院心脏大血管外科,太原 030024
- 折叠
摘要
Abstract
Cardiovascular disease is a leading cause of morbidity and mortality in humans today.Maintenance of the structure and homeostasis of the cardiovascular system by mammalian cardiac and vascular cells makes cellular death crucial for the development of cardiac and vascular homeostasis.Ferroptosis is a regulatory form of cell death based on iron-driven lipid peroxidation mechanisms,widely involved in stress-induced cell death in cardiac and vascular cells.Under the catalysis of iron,disruption of lipid hydroperoxide metabolism within cells leads to inactivation of glutathione peroxidase 4,thereby disrupting oxidation-reduction homeostasis and ultimately triggering cell death.Metabolism of amino acids,iron,lipids,and related pathways are considered specific biomarkers for ferroptosis.Ferroptosis plays an important role in the pathophysiological processes of cardiovascular diseases such as atherosclerosis,aortic dissection,aneurysms,ischemia-reperfusion,ischemic stroke,heart failure,myocardial ischemia-reperfusion injury,cardiomyopathy,pulmonary hypertension,calcific vascular disease,and valvular diseases.关键词
调节性细胞死亡/铁死亡/铁稳态/心血管疾病Key words
regulated cell death/ferroptosis/iron homeostasis/cardiovascular diseases引用本文复制引用
吴楠,杨涛,胡玉原,程心萌,刘振豪,王学宁..铁稳态、铁死亡与心血管疾病[J].临床与病理杂志,2024,44(2):295-306,12.
