临床与病理杂志2024，Vol.44Issue(2)：313-319,7.DOI:10.11817/j.issn.2095-6959.2024.230431
脊柱手术后认知功能障碍和术后谵妄
Cognitive dysfunction and postoperative delirium after spinal surgery
摘要
Abstract
Postoperative cognitive dysfunction and postoperative delirium are 2 major manifestations of perioperative neurocognitive dysfunction(PND).They are relatively common after spinal surgery and have a significant negative impact on the patient's postoperative recovery and quality of life.In addition to known risk factors such as age and educational level,intraoperative hypotension and hypothermia are also important triggers for the occurrence of PND.The underlying pathological mechanisms may involve an enhanced neuroinflammatory response and reduced neurotransmitter levels.Moreover,certain anesthetics,such as dexmedetomidine and esketamine,have been shown to potentially prevent PND by inhibiting the inflammatory process.关键词
脊柱手术/术后认知功能障碍/术后谵妄/神经炎症Key words
spine surgery/postoperative cognitive dysfunction/postoperative delirium/neuroinflammation引用本文复制引用
刘东,陶庆宇,朱海娟,余骏马..脊柱手术后认知功能障碍和术后谵妄[J].临床与病理杂志,2024,44(2):313-319,7.基金项目
安徽省卫生健康委员会科研项目(2022-145).This work was supported by the Research Project of Anhui Health Committee,China(2022-145). （2022-145）
