基础医学与临床2024，Vol.44Issue(6)：748-752,5.DOI:10.16352/j.issn.1001-6325.2024.06.0748
肾上腺皮质癌基因及分子机制
Genetic and molecular mechanism changes of adrenocortical carcinoma
摘要
Abstract
Adreno-cortical carcinoma(ACC)is an uncommon tumor,some of them may produce excessive steroid hormone.The prognosis of ACC is quite poor and current treatment options are relatively limited,especially for pa-tients whose tumor is metastatic and difficult to remove by surgical operation.This makes the management of ACC challenging.Existing studies have shown that the mechanisms of ACC are complex.The molecular changes happen in adrenocortical development and homeostasis may explain the occurrence of ACC.This review focuses on recent studies and summarizes the genetic and molecular mechanism changes that potentially associated with ACC in the development process of the adrenal cortex and multi-omics studies,including genomic changes,epigenetic changes,differences in non-coding RNA,immune microenvironment and features found through multi-omics analy-sis.This information may support screening of therapeutic targets of ACC in future.关键词
肾上腺皮质癌/肾上腺皮质发育/分子机制/多组学研究Key words
adrenocortical carcinoma/adrenocortical development/molecular mechanism/multiple omics studies分类
医药卫生引用本文复制引用
刘晶华,卢琳..肾上腺皮质癌基因及分子机制[J].基础医学与临床,2024,44(6):748-752,5.基金项目
国家重点研发计划项目常见多发病防治研究专项(2022YFC2505300,子课题:2022YFC2505304) （2022YFC2505300,子课题:2022YFC2505304）
