基础医学与临床2024，Vol.44Issue(6)：753-757,5.DOI:10.16352/j.issn.1001-6325.2024.06.0753
肾上腺皮质球状带细胞的电兴奋性与醛固酮分泌:离子通道的作用
Electrical excitability and aldosterone secretion in the zona glomerulosa cells:the role of ion channels
摘要
Abstract
Aldosterone is a kind of steroid hormone produced by the zona glomerulosa(ZG)cells of the adre-nal cortex which plays a crucial regulatory role in fluid-electrolyte balance and blood pressure stability.Aldo-sterone biosynthesis is a calcium-dependent process,and ion channels play a key role in this process.Primary aldosteronism is closely related to mutations in ion channels.Recent studies have highlighted an intriguing rela-tionship between the unique rosette structure of ZG cells and their electrical excitability.Elucidating the con-nection between rosettes and ZG cell electrical excitability as well as aldosterone secretion leads to a deeper un-derstanding of the mechanisms regulating aldosterone secretion and may provide new insights into the pathogen-esis of primary aldosteronism.关键词
肾上腺皮质球状带细胞/电兴奋性/醛固酮/离子通道/rosette结构Key words
zona glomerulosa cells/electrical excitability/aldosterone/ion channels/rosette structure分类
生物科学引用本文复制引用
张雪峰,胡长龙..肾上腺皮质球状带细胞的电兴奋性与醛固酮分泌:离子通道的作用[J].基础医学与临床,2024,44(6):753-757,5.基金项目
上海市自然科学基金(23ZR1425900) （23ZR1425900）
