基础医学与临床2024，Vol.44Issue(6)：887-891,5.DOI:10.16352/j.issn.1001-6325.2024.06.0887
肠道菌群代谢物次级胆汁酸调控宿主免疫功能
Regulation of host immune function by gut microbiota-derived secondary bile acids
摘要
Abstract
Disturbances of gut microbiota may affect the balance of the host immune system.The metabolism of gut microbiota produces many bioactive molecules interacting with host,typically secondary bile acids(SBAs).SBAs are involved in regulating the energy metabolism and the expression of inflammatory response-related genes by bind-ing to membrane receptors and nuclear receptors,such as takeda G protein-coupled receptor(TGR5)and farnesol X receptor(FXR),which are essential for maintaining host immune homeostasis.关键词
肠道菌群/次级胆汁酸/免疫调控Key words
gut microbiota/secondary bile acids/immune regulation分类
医药卫生引用本文复制引用
岳玲玲,王梓潓,李小芹,李利锋,张万存,于志丹..肠道菌群代谢物次级胆汁酸调控宿主免疫功能[J].基础医学与临床,2024,44(6):887-891,5.基金项目
国家自然科学基金(81903330) （81903330）
河南省科技攻关(202102310071) （202102310071）
河南省医学科技攻关(SBGJ202303047) （SBGJ202303047）
