基础医学与临床2024，Vol.44Issue(6)：892-896,5.DOI:10.16352/j.issn.1001-6325.2024.06.0892
CXCL10/CXCR3轴在急性呼吸窘迫综合征中的作用
The CXCL10/CXCR3 axis in acute respiratory distress syndrome
摘要
Abstract
The CXC chemokine ligand-10/CXC receptor-3(CXCL10/CXCR3)axis,a crucial pathway mediating Th1-type immunity,substantially contributes to the development of acute respiratory distress syndrome(ARDS)by enhancing inflammatory storms.It additionally promotes vascular endothelial apoptosis and impedes vasculature re-pair,elevating the risk of pulmonary vascular thrombosis.Conversely,this axis plays a protective role in limiting extra-cellular matrix deposition and modulating cell migration,thereby mitigating pulmonary fibrosis.The various mechanisms of the CXCL10/CXCR3 axis in the pathogenesis and progression of ARDS could offer novel insights for the diagnosis and treatment of ARDS.关键词
CXCL10/CXCR3/急性呼吸窘迫综合征/炎性反应/肺血管栓塞/肺纤维化Key words
CXCL10/CXCR3 axis/acute respiratory distress syndrome/inflammations/pulmonary embolism/pulmonary fibrosis分类
医药卫生引用本文复制引用
盛琪,童瑾..CXCL10/CXCR3轴在急性呼吸窘迫综合征中的作用[J].基础医学与临床,2024,44(6):892-896,5.基金项目
重庆市卫生适宜技术推广项目(2022jstg021) （2022jstg021）
