慢性阻塞性肺疾病患者焦虑与脑功能活动异常的相关性研究OACSTPCD

Objective To analyze the correlation between anxiety symptoms and abnormal brain function in patients with chronic obstructive pulmonary disease(COPD)under long-term chronic hy-poxia.Methods Twenty-one patients with COPD complicated with anxiety were prospectively select-ed as COPD group,and 26 healthy individuals matched for gender and age were selected as control group.Both groups underwent high-resolution 3D-T1-weighted imaging(3D-T1WI),T2-fluid-attenua-ted inversion recovery(T2-FLAIR),and blood oxygen level dependent(BOLD)sequence examina-tion.DPARSF and SPM8 software were used to analyze the amplitude of low-frequency fluctuations(ALFF)in the brain of the two groups.Results In the COPD group,the ALFF value in the left parahippocampal gyrus-cingulate gyrus increased,and the ALFF value in the right superior frontal gy-rus decreased(P＜0.05).Pearson correlation analysis found that there was a negative correlation be-tween the ALFF value in the right superior frontal gyrus and the anxiety score(r=-0.485,P=0.03).Conclusion Chronic hypoxic patients with COPD have brain functional impairment in the right superior frontal gyrus,and the degree of impairment is positively correlated with anxiety symp-toms.There may also be compensatory enhancement of brain function activity in the parahippocampal gyrus-cingulate gyrus.