实用临床医药杂志2024，Vol.28Issue(8)：79-82,4.DOI:10.7619/jcmp.20240060
慢性阻塞性肺疾病患者焦虑与脑功能活动异常的相关性研究
Correlation between anxiety symptoms and abnormal brain function in chronic obstructive pulmonary disease
摘要
Abstract
Objective To analyze the correlation between anxiety symptoms and abnormal brain function in patients with chronic obstructive pulmonary disease(COPD)under long-term chronic hy-poxia.Methods Twenty-one patients with COPD complicated with anxiety were prospectively select-ed as COPD group,and 26 healthy individuals matched for gender and age were selected as control group.Both groups underwent high-resolution 3D-T1-weighted imaging(3D-T1WI),T2-fluid-attenua-ted inversion recovery(T2-FLAIR),and blood oxygen level dependent(BOLD)sequence examina-tion.DPARSF and SPM8 software were used to analyze the amplitude of low-frequency fluctuations(ALFF)in the brain of the two groups.Results In the COPD group,the ALFF value in the left parahippocampal gyrus-cingulate gyrus increased,and the ALFF value in the right superior frontal gy-rus decreased(P＜0.05).Pearson correlation analysis found that there was a negative correlation be-tween the ALFF value in the right superior frontal gyrus and the anxiety score(r=-0.485,P=0.03).Conclusion Chronic hypoxic patients with COPD have brain functional impairment in the right superior frontal gyrus,and the degree of impairment is positively correlated with anxiety symp-toms.There may also be compensatory enhancement of brain function activity in the parahippocampal gyrus-cingulate gyrus.关键词
慢性阻塞性肺疾病/低氧/焦虑/磁共振成像/血氧水平/低频振幅Key words
chronic obstructive pulmonary disease/hypoxia/anxiety/magnetic resonance ima-ging/blood oxygen level/low-frequency amplitude分类
医药卫生引用本文复制引用
马洪鸽,王龙龙,成莎,王亮亮,高延忠,马静文,李娜,王警建,李小娥..慢性阻塞性肺疾病患者焦虑与脑功能活动异常的相关性研究[J].实用临床医药杂志,2024,28(8):79-82,4.基金项目
陕西省西安市科技计划项目(22YXYJ0055) （22YXYJ0055）
