基础医学与临床2024，Vol.44Issue(6)：742-747,6.DOI:10.16352/j.issn.1001-6325.2024.06.0742
嗜铬细胞瘤/副神经节瘤免疫微环境
Immune microenvironment of pheochromocytomas and paragangliomas
摘要
Abstract
Pheochromocytomas/Paragangliomas(PPGLs)are rare neuroendocrine tumors with a high hereditary predisposition.The pseudo-hypoxic PPGLs dominated by SDHx mutations show a higher potential of metastasis.Ap-proximately 10%-17%of PPGLs develop metastasis and patients with metastatic diseases have restricted treatment options and a poor prognosis.Tumor immune microenvironment(TIME)plays a crucial role in the development and progression of tumors as well as predicting patients'prognosis and their response to immune checkpoint inhibitors.Several studies have initially characterized the immune landscape of PPGLs.This review focuses on the infiltration of immune cells,the expression of immune checkpoints in the TIME of PPGLs and their relationships with genetics and metastasis of tumors in order to better understand the mechanisms of tumor immune evasion in PPGLs and pro-vide insights to support novel treatment strategy for metastatic PPGLs.关键词
嗜铬细胞瘤/副神经节瘤/转移性嗜铬细胞瘤/副神经节瘤/肿瘤免疫微环境/免疫细胞/免疫检查点Key words
pheochromocytomas/paragangliomas/metastatic pheochromocytomas/paragangliomas/tumor immune microenvironment/immune cell/immune checkpoint分类
临床医学引用本文复制引用
周玥,童安莉..嗜铬细胞瘤/副神经节瘤免疫微环境[J].基础医学与临床,2024,44(6):742-747,6.基金项目
中央高水平医院临床研究专项(2022-PUMCH-C-028) （2022-PUMCH-C-028）
中国医学科学院医学与健康科技创新工程(2021-I2M-C&T-B-002) （2021-I2M-C&T-B-002）
