实用临床医药杂志2024，Vol.28Issue(8)：16-21,6.DOI:10.7619/jcmp.20233021
磁共振成像技术在2型糖尿病痛性神经病变患者中的应用
Application of magnetic resonance imaging in patients with type 2 diabetic painful neuropathy
摘要
Abstract
Objective To observe the application effect of magnetic resonance imaging technology in evaluating the brain structure and function of patients with type 2 diabetic painful neuropathy(PDN).Methods Forty patients with type 2 diabetes mellitus hospitalized in our hospital were se-lected as the study objects,and were divided into diabetes mellitus(DM)group(n=12),peripheral neuropathy(DPN)group(n=14)and PDN group(n=14).General clinical biochemical indexes of three groups were analyzed.The structural brain and function of brain area in three groups were com-pared.Results Age,duration of diabetes,systolic blood pressure,diastolic blood pressure,fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),free fatty acid(FFA),albumin(ALB),creatinine(Cr),uric acid(UA),estimated glomerular filtration rate(eGFR),cystatin C(Cys-C),total cholesterol(TC),triglyceride(TG)of the three groups were compared,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triiodothyronine(T3),thyroxine(T4),thyroid stimulating hormone(TSH),thyroglobulin antibody(TGAb),thyroid peroxidase anti-body(TPO-Ab)and serum calcium(Ca)in the three groups showed no significant differences(P＞0.05).Compared with the DM group,the gray matter volume(GMV)in the DPN group was signifi-cantly decreased(P＜0.05).Compared with the DM group,amplitude of low frequency fluctuation(ALFF)and fractional amplitude of low frequency fluctuation(fALFF)of left medial superiorfrontal gyrus in the PDN group were significantly decreased(P＜0.05).Conclusion Abnormal GMV in the left angular gyrus in DPN patients may be associated with a higher risk of concomitant cognitive impairment.The decrease of ALFF in the right cerebellar vermis and fALFF in the left medial superior frontal gyrus in PDN patients may be related to the pathogenesis of pain.关键词
糖尿病/糖尿病周围神经病变/糖尿病痛性神经病变/磁共振成像/灰质体积/低频振幅Key words
diabetes mellitus/diabetes peripheral neuropathy/diabetic painful neuropathy/magnetic resonance imaging/gray matter volume/amplitude of low frequency fluctuation分类
医药卫生引用本文复制引用
王淑倩,惠灿灿,程雨微,胡秀娟,印小蓉,崔梦捷,黄沁仪,尹杨柳,孙艳..磁共振成像技术在2型糖尿病痛性神经病变患者中的应用[J].实用临床医药杂志,2024,28(8):16-21,6.基金项目
安徽省高校自然科学基金重点项目(KJ2018A0196) （KJ2018A0196）
安徽省高校科研项目(2023AH053309) （2023AH053309）
安徽医科大学校科研基金项目(2021xkj144) （2021xkj144）
安徽医科大学第一附属医院临床研究项目(LCYJ2021YB006) （LCYJ2021YB006）
