临床肝胆病杂志2024，Vol.40Issue(5)：1016-1020,5.DOI:10.12449/JCH240523
高频不可逆电穿孔消融猪胰腺组织的效果观察
Effect of high-frequency irreversible electroporation in the ablation of porcine pancreatic tissue
摘要
Abstract
Objective To investigate the effect of high-frequency irreversible electroporation(H-FIRE)in the ablation of pig pancreatic tissue.Methods Laparotomy was conducted in this study,and needle electrodes were used to release electric pulses in 12 pigs.Three sets of parameters were established for ablation at the low,medium,and high values of field strength(1 000 V/cm,1 500 V/cm,and 2 500 V/cm).The groups were compared in terms of the data including postoperative recovery,ablation area,and histopathological features to validate the safety and efficacy of H-FIRE in the ablation of porcine pancreatic tissue.The paired t-test was used for comparison of continuous data between two groups.Results All pigs in the experiment survived and showed a good effect of ablation.The histopathological analysis of all groups showed thorough and effective ablation,with a clear boundary between the ablated area and the normal tissue area.The mean ablation area in the low,medium,and high field strength groups was 30.96±3.73 mm2,51.93±25.26 mm2,and 108.90±55.23 mm2,respectively,and the high and medium field strength groups had a significantly larger ablation area than the low field strength group(both P<0.05),while there was no significant difference in ablation area between the medium and high field strength groups(P>0.05).Conclusion H-FIRE ablation is safe and effective for porcine pancreatic tissue under specific ablation parameters.关键词
胰腺肿瘤/电穿孔/消融技术/动物实验Key words
Pancreatic Neoplasms/Electroporation/Ablation Techniques/Animal Experimentation引用本文复制引用
幸嵘,杜霁儒,翁原驰,王峰,刘超..高频不可逆电穿孔消融猪胰腺组织的效果观察[J].临床肝胆病杂志,2024,40(5):1016-1020,5.基金项目
山东省自然科学基金面上项目(ZR2023MH111) Shandong Provincial Natural Science Foundation Project(ZR2023MH111) （ZR2023MH111）
