实用临床医药杂志2024，Vol.28Issue(8)：50-54,5.DOI:10.7619/jcmp.20233513
颅脑术后继发颅内感染患者脑脊液膜联蛋白A2和S100钙结合蛋白A10表达水平及临床意义
Expression levels and clinical significance of cerebrospinal fluid Annexin A2 and S100 calcium binding protein A10 levels in patients with secondary intracranial infection after craniocerebral surgery
摘要
Abstract
Objective To investigate expression levels and clinical significance of annexin A2 and S100 calcium binding protein A10(S100A10)in cerebrospinal fluid of patients with secondary in-tracranial infection after craniocerebral surgery.Methods A total of 120 patients with secondary in-tracranial infection after craniocerebral surgery were selected as test group,while 120 patients with no infection after craniocerebral surgery in the same period were selected as control group.The levels of Annexin A2 and S100A10 in cerebrospinal fluid were detected by enzyme-linked immunosorbent assay(ELISA).Pearson correlation analysis was applied to analyze the correlations of Annexin A2 and S100A10 with clinical indicators.Logistic regression analysis was applied to analyze the influencing factors of secondary intracranial infection after craniocerebral surgery.Receiver operator characteristic(ROC)curve was applied to analyze the predictive value of Annexin A2 and S100A10 levels for the occurrence of secondary intracranial infection after craniocerebral surgery.Results The proportions of diabetes and cerebrospinal fluid leakages,blood 1 actate dehydrogenase(LDH),cerebrospinal fluid Annexin A2 and S100A10 levels in the test group were higher than those in the control group(P＜0.05).Annexin A2 in cerebrospinal fluid of patients with intracranial infection was positively correlated with S100A10,LDH,and S100A10 level was positively correlated with LDH(P＜0.05).Multiva-riate Logistic regression analysis showed that diabetes,cerebrospinal fluid leakage,blood LDH,An-nexin A2 and S1 00Al0 in cerebrospinal fluid were independent influencing factors for secondary in-tracranial infection after craniocerebral surgery(P＜0.05).ROC results showed that the AUCs of Annexin A2 level or S100A1 0 level alone in cerebrospinal fluid and their combined prediction for secondary intracranial infection after craniocerebral surgery was 0.788,0.768 and 0.865 respec-tively,the AUC of combined prediction was larger than that of the single prediction(P＜0.05).Conclusion The expression levels of Annexin A2 and S100A10 are increased in cerebrospinal fluid of patients with secondary intracranial infection after craniocerebral surgery,which are independent influencing factors for secondary intracranial infection after craniocerebral surgery.Their combina-tion has higher predictive value for secondary intracranial infection after craniocerebral surgery.关键词
颅脑手术/颅内感染/膜联蛋白A2/S100钙结合蛋白A10/临床意义/预测价值Key words
craniocerebral surgery/intracranial infection/annexin A2/S100 calcium bind-ing protein A10/clinical significance/predictive value分类
临床医学引用本文复制引用
曾东,李璐,郑鸿翔,王真珍..颅脑术后继发颅内感染患者脑脊液膜联蛋白A2和S100钙结合蛋白A10表达水平及临床意义[J].实用临床医药杂志,2024,28(8):50-54,5.基金项目
2022年河南省医学科技攻关计划联合共建项目(LHGJ20220847) （LHGJ20220847）
