临床肝胆病杂志2024，Vol.40Issue(5)：1026-1031,6.DOI:10.12449/JCH240525
HBeAg诱导的免疫激活和免疫抑制在慢性乙型肝炎中的作用
Role of HBeAg-induced immune activition and immunosuppression in chronic hepatitis B
摘要
Abstract
Chronic hepatitis B induced by HBV infection is a significant risk factor leading to liver cirrhosis and liver cancer.Half a century ago,HBeAg was first discovered in the serum of HBV infected individuals,and although HBeAg does not participate in HBV infection or replication in hepatocytes,studies have shown that it can interfere with the innate and adaptive immune responses of the host and play an important role in immune activation and immunosuppression during chronic HBV infection.HBV has no cytotoxicity to the infected hepatocytes,and the antiviral action and inflammatory response mediated by immune response determine whether HBV is cleared or induces liver inflammation-related diseases.Therefore,this article reviews the formation of HBeAg and its immune activation and immunosuppression mechanisms in chronic HBV infection,with a focus on the different immune effects caused by HBeAg on innate immune and adaptive immune cells,and this article also elaborates on the dual role of HBeAg in inducing immune responses and explores the conversion role of HBeAg in different stages of chronic HBV infection.关键词
乙型肝炎,慢性/乙型肝炎e抗原/免疫激活/免疫抑制Key words
Hepatitis B,Chronic/Hepatitis B e Antigens/Immune Activation/Immune Suppressive引用本文复制引用
李欣阳,涂正坤..HBeAg诱导的免疫激活和免疫抑制在慢性乙型肝炎中的作用[J].临床肝胆病杂志,2024,40(5):1026-1031,6.基金项目
吉林省科技发展计划项目自然科学基金(20190201245JC) Jilin Province Science and Technology Development Plan Project Natural Science Foundation Project(20190201245JC) （20190201245JC）
