肝巨噬细胞调控肝癌癌前病变恶变的研究进展
Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions
摘要
Abstract
Liver macrophages are important immune cells in the liver,and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type,respectively,thereby playing a role in regulating inflammatory damage response.The malignant transformation of hepatic progenitor cells is the core mechanism of the malignant progression of hepatic precancerous lesions,and its key factor is the continuous stimulation of inflammatory microenvironment,which is closely associated with M1/M2 macrophage polarization.This review mainly focuses on the association between macrophage polarization,chronic inflammation,and malignant transformation of hepatic progenitor cells,so as to provide a theoretical basis for the prevention and treatment of hepatic precancerous lesions.关键词
癌,肝细胞/肝巨噬细胞/肝祖细胞恶变Key words
Carcinoma,Hepatocellular/Liver Macrophage/Hepatic Progenitor Cell Malignant Transformation引用本文复制引用
闫瑞娟,焦俊喆,黄玉,闫曙光,魏海梁,常占杰,郭英君,李京涛..肝巨噬细胞调控肝癌癌前病变恶变的研究进展[J].临床肝胆病杂志,2024,40(5):1039-1043,5.基金项目
国家自然科学基金(82174330) （82174330）
陕西省科技厅科研基金(2022JQ-965,2020ZDLSF05-15) （2022JQ-965,2020ZDLSF05-15）
陕西省科技厅创新团队(2022TD-55) （2022TD-55）
陕西省中管局创新团队(2022-SLRH-LJ-002) （2022-SLRH-LJ-002）
咸阳市科技局科研基金(L2022ZDYFSF007) （L2022ZDYFSF007）
宁夏自然科学基金(2023AAC03510) （2023AAC03510）
陕西中医药大学学科创新团队建设项目(2019-YL05) National Natural Science Foundation of China(82174330) （2019-YL05）
Science and Technology Department of Shaanxi Research Fund(2022JQ-965,2020ZDLSF05-15) （2022JQ-965,2020ZDLSF05-15）
Innovation Team of Science and Technology Department of Shaanxi Province(2022TD-55) （2022TD-55）
Innovation Team of TCM Administration of Shaanxi Province(2022-SLRH-LJ-002) （2022-SLRH-LJ-002）
Science and Technology Administration of Xianyang City Scientific Research Fund(L2022ZDYFSF007) （L2022ZDYFSF007）
Natural Science Foundation of Ningxia(2023AAC03510) （2023AAC03510）
Discipline Innovation Team Building Project of Shaanxi University of Chinese Medicine(2019-YL05) （2019-YL05）
