Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用
The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases
摘要
Abstract
The Wnt signaling pathway plays an important role in maintaining liver homeostasis and liver regeneration.In healthy livers,the Wnt signaling pathway is mostly inactive,but it is continuously overactivated during cell renewal or regeneration processes,as well as in certain pathological conditions,diseases,precancerous states,and cancers.Persistent liver cell injury often leads to chronic liver diseases such as liver fibrosis,liver cirrhosis,and liver cancer.This article summarizes the basic structural features of the Wnt signaling pathway and analyzes its important role in the pathological progression of various liver diseases,so as to provide new ideas for the prevention and treatment of liver diseases in clinical practice.关键词
肝疾病/肝再生/Wnt信号通路/β连环素Key words
Liver Diseases/Liver Regeneration/Wnt Signaling Pathway/beta Catenin引用本文复制引用
林玉培,刘晓萍,罗银冰,李飞燕,廖莹莹,莫世聪,毛德文,蓝艳梅..Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用[J].临床肝胆病杂志,2024,40(5):1050-1056,7.基金项目
国家自然科学基金(81960841,82274434) （81960841,82274434）
广西自然科学基金(2020GXNSFBA297115,2023GXNSFAA026176) （2020GXNSFBA297115,2023GXNSFAA026176）
广西自然科学基金创新研究团队项目(2020GXNSFAA297070) （2020GXNSFAA297070）
广西高校中青年教师科研基础能力提升项目(2022KY0299) （2022KY0299）
广西中医药大学校级一般硕士研究生创新项目(YCSY2022024) Natioanal Natural Science Foundation Project(81960841,82274434) （YCSY2022024）
Guangxi Natural Science Foundation Project(2020GXNSFBA297115,2023GXNSFAA026176) （2020GXNSFBA297115,2023GXNSFAA026176）
Guangxi Natual Science Foundation Innovation Research Team Project(2020GXNSFAA297070) （2020GXNSFAA297070）
Guangxi University Young and Middle School Teachers'Basic Research Ability Enhancement Project(2022KY0299) （2022KY0299）
Innovation Project of General Post graduates in Guangxi University of Traditional Chinese Medicine(YCSY2022024) （YCSY2022024）
