临床误诊误治2024，Vol.37Issue(6)：42-47,6.DOI:10.3969/j.issn.1002-3429.2024.06.009
血清CTRP9、Gal-3与慢性心力衰竭患者室性心律失常关系及对室性心律失常预测价值
Relationship between Serum CTRP9 and Gal-3 Levels and Ventricular Ar-rhythmia in Patients with Chronic Heart Failure and Their Predictive Val-ue for Ventricular Arrhythmia
摘要
Abstract
Objective To investigate the relationship between serum levels of complement C1q tumor necrosis factor related protein 9(CTRP9)and galactose agglutinin 3(Gal-3)and ventricular arrhythmia in patients with chronic heart failure(CHF),and their predictive value for ventricular arrhythmia.Methods A total of 120 patients with CHF admitted from Oc-tober 2021 to October 2022 were selected and divided into occurrence group(n=41)and non-occurrence group(n=79)ac-cording to occurrence of ventricular arrhythmia.Clinical data and serum CTRP9 and Gal-3 levels of the two groups were com-pared to analyze the influencing factors of ventricular arrhythmia in CHF patients.The impact of serum CTRP9 and Gal-3 in-teraction on the risk of ventricular arrhythmia in CHF patients was analyzed,and the predictive value of serum CTRP9 and Gal-3 on ventricular arrhythmia in CHF patients was evaluated.The prognosis of CHF patients with different serum CTRP9 and Gal-3 levels was compared.Results There were significant differences in cardiac function grade,left ventricular ejection fraction and average heart rate between the two groups(P＜0.01).The serum CTRP9 level in the occurrence group was lower than that in the non-occurrence group,while the serum Gal-3 level was higher than that in the non-occurrence group(P＜0.01).Logistic regression analysis showed that cardiac function grade,left ventricular ejection fraction,average heart rate,and serum CTRP9 and Gal-3 levels were all influencing factors for ventricular arrhythmia in CHF patients(P＜0.01),and there was additive interaction between serum CTRP9 and Gal-3 levels.Receiver operating characteristic(ROC)curve analysis showed that the area under the ROC curve of serum CTRP9 and Gal-3 in combination in predicting ventricular arrhythmia in CHF patients was 0.941,which was higher than that predicted by each index alone(0.802 and 0.714,respectively).Taking the mean values of serum CTRP9 and Gal-3 in 120 CHF patients as the boundary,the incidence rate of adverse cardiovascular events in patients with high serum CTRP9 level was lower than that in patients with low CTRP9 level,while the incidence rate of adverse cardiovascular events in patients with high serum Gal-3 level was higher than that in patients with low Gal-3 level(P＜0.05).Conclusion The decrease of CERP9 level and the increase of Gal-3 level in CHF patients are related to the oc-currence of ventricular arrhythmia.Clinical detection of serum CERP9 and Gal-3 is helpful to predict the risk of ventricular ar-rhythmia.关键词
心力衰竭/心律失常/补体C1q肿瘤坏死因子相关蛋白9/半乳糖凝集素-3/心功能/心率/左室射血分数/Logistic回归分析Key words
Heart failure/Arrhythmia/Complement C1q tumor necrosis factor-associated protein 9/Galectin-3/Cardiac function/Heart rate/Left ventricular ejection fraction/Logistic regression analysis分类
临床医学引用本文复制引用
袁玉敏,宋蕾,卢英民,岳冬梅..血清CTRP9、Gal-3与慢性心力衰竭患者室性心律失常关系及对室性心律失常预测价值[J].临床误诊误治,2024,37(6):42-47,6.基金项目
上海市崇明区"可持续发展科技创新行动计划"项目(CKY2022-08) （CKY2022-08）
