血清CTRP9、Gal-3与慢性心力衰竭患者室性心律失常关系及对室性心律失常预测价值OACSTPCD
Relationship between Serum CTRP9 and Gal-3 Levels and Ventricular Ar-rhythmia in Patients with Chronic Heart Failure and Their Predictive Val-ue for Ventricular Arrhythmia
目的 探究血清补体C1q肿瘤坏死因子相关蛋白 9(CTRP9)和乳糖凝集素-3(Gal-3)与慢性心力衰竭(CHF)患者室性心律失常关系及对室性心律失常预测价值.方法 选取 2021 年 10 月—2022 年 10 月收治的CHF 120 例,根据是否发生室性心律失常分为发生组(41 例)和未发生组(79 例).比较 2 组临床资料及血清 CTRP9、Gal-3,分析CHF患者室性心律失常影响因素,探讨血清CTRP9 和Gal-3 交互作用对CHF患者室性心律失常发生风险影响,评价血清CTRP9 和Gal-3 对CHF患者室性心律失常预测价值,比较不同血清CTRP9 和Gal-3 水平CHF患者预后情况.结果 发生组心功能分级、左室射血分数及平均心率与未发生组比较差异有统计学意义(P＜0.01);发生组血清CTRP9 低于未发生组,血清Gal-3 高于未发生组(P＜0.01).Logistic回归分析显示,心功能分级、左室射血分数、平均心率及血清CTRP9、Gal-3 均为CHF患者室性心律失常影响因素(P＜0.01),且血清CTRP9 和Gal-3 间存在相加交互作用.受试者工作特征曲线显示,血清CTRP9 和Gal-3 联合预测CHF患者室性心律失常的曲线下面积为0.941,高于单独预测的0.802 和0.714(P＜0.01).以CHF 120 例血清CTRP9 和Gal-3 平均值为界,血清CTRP9 高水平患者心血管不良事件发生率低于血清CTRP9 低水平患者,而血清Gal-3 高水平患者心血管不良事件发生率高于血清Gal-3低水平患者(P＜0.05).结论 CHF患者血清CERP9 下降、Gal-3 升高,与室性心律失常发生有关.临床检测CHF患者血清CTRP9 和Gal-3 有助于预测室性心律失常发生风险.
Objective To investigate the relationship between serum levels of complement C1q tumor necrosis factor related protein 9(CTRP9)and galactose agglutinin 3(Gal-3)and ventricular arrhythmia in patients with chronic heart failure(CHF),and their predictive value for ventricular arrhythmia.Methods A total of 120 patients with CHF admitted from Oc-tober 2021 to October 2022 were selected and divided into occurrence group(n=41)and non-occurrence group(n=79)ac-cording to occurrence of ventricular arrhythmia.Clinical data and serum CTRP9 and Gal-3 levels of the two groups were com-pared to analyze the influencing factors of ventricular arrhythmia in CHF patients.The impact of serum CTRP9 and Gal-3 in-teraction on the risk of ventricular arrhythmia in CHF patients was analyzed,and the predictive value of serum CTRP9 and Gal-3 on ventricular arrhythmia in CHF patients was evaluated.The prognosis of CHF patients with different serum CTRP9 and Gal-3 levels was compared.Results There were significant differences in cardiac function grade,left ventricular ejection fraction and average heart rate between the two groups(P＜0.01).The serum CTRP9 level in the occurrence group was lower than that in the non-occurrence group,while the serum Gal-3 level was higher than that in the non-occurrence group(P＜0.01).Logistic regression analysis showed that cardiac function grade,left ventricular ejection fraction,average heart rate,and serum CTRP9 and Gal-3 levels were all influencing factors for ventricular arrhythmia in CHF patients(P＜0.01),and there was additive interaction between serum CTRP9 and Gal-3 levels.Receiver operating characteristic(ROC)curve analysis showed that the area under the ROC curve of serum CTRP9 and Gal-3 in combination in predicting ventricular arrhythmia in CHF patients was 0.941,which was higher than that predicted by each index alone(0.802 and 0.714,respectively).Taking the mean values of serum CTRP9 and Gal-3 in 120 CHF patients as the boundary,the incidence rate of adverse cardiovascular events in patients with high serum CTRP9 level was lower than that in patients with low CTRP9 level,while the incidence rate of adverse cardiovascular events in patients with high serum Gal-3 level was higher than that in patients with low Gal-3 level(P＜0.05).Conclusion The decrease of CERP9 level and the increase of Gal-3 level in CHF patients are related to the oc-currence of ventricular arrhythmia.Clinical detection of serum CERP9 and Gal-3 is helpful to predict the risk of ventricular ar-rhythmia.
袁玉敏;宋蕾;卢英民;岳冬梅
202150 上海,上海健康医学院附属崇明医院心血管内科
临床医学
心力衰竭心律失常补体C1q肿瘤坏死因子相关蛋白9半乳糖凝集素-3心功能心率左室射血分数Logistic回归分析
Heart failureArrhythmiaComplement C1q tumor necrosis factor-associated protein 9Galectin-3Cardiac functionHeart rateLeft ventricular ejection fractionLogistic regression analysis
《临床误诊误治》 2024 (006)
42-47 / 6
上海市崇明区"可持续发展科技创新行动计划"项目(CKY2022-08)
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