临床肝胆病杂志2024，Vol.40Issue(5)：870-874,5.DOI:10.12449/JCH240504
儿童HBV感染:ALT水平正常患儿的抗病毒治疗
Hepatitis B virus infection in children:Antiviral therapy for children with a normal alanine aminotransferase level
傅蕾1
作者信息
- 1. 中南大学湘雅医院感染病科,长沙 410008
- 折叠
摘要
Abstract
Chronic hepatitis B(CHB)is a major public health issue around the world,and there are currently about 2 million children with hepatitis B virus(HBV)infection in China.HBV infection in children tends to become chronic,leading to high risks of liver cirrhosis and liver cancer in adulthood.Traditionally,it is believed that children with HBV infection are mainly in the immune-tolerant phase and do not require antiviral therapy,and antiviral therapy is only initiated for CHB children who are in the immune-active phase or suffer from compensated or decompensated liver cirrhosis.More and more clinical studies on CHB in children have shown that CHB children tend to have a high response rate to antiviral therapy,especially interferon-based regimens,and young children are at the advantage of clinical cure;however,there are still controversies over whether antiviral therapy should be initiated for children with HBV infection who have a normal alanine aminotransferase(ALT)level and are in the immune-tolerant phase.This article reviews the features of children with HBV infection and the necessity of antiviral therapy for children with a normal ALT level,with a special focus on treatment timing.关键词
乙型肝炎病毒/丙氨酸转氨酶/治疗学/儿童Key words
Hepatitis B virus/Alanine Transaminase/Therapeutics/Child引用本文复制引用
傅蕾..儿童HBV感染:ALT水平正常患儿的抗病毒治疗[J].临床肝胆病杂志,2024,40(5):870-874,5.
