临床误诊误治2024，Vol.37Issue(6)：95-100,6.DOI:10.3969/j.issn.1002-3429.2024.06.018
疏肝健脾解毒方辅助光动力疗法对女性尖锐湿疣患者HPV病毒载量及免疫调节的作用
Role of Shugan Jianpi Jiedu Prescription Assisted Photodynamic Therapy in HPV Viral Load and Immune Regulation in Female Patients with Condy-loma Acuminatum
摘要
Abstract
Objective To observe the effects of Shugan Jianpi Jiedu prescription assisted photodynamic therapy on human papillomavirus(HPV)viral load and immune regulation in female patients with condyloma acuminatum(CA).Meth-ods A total of 108 female patients with CA treated from March 2022 to October 2022 were selected and divided into two groups,with 54 cases in each group,by random number table method.Both groups received conventional basic treatment,control group was supplemented with photodynamic therapy,and observation group was supplemented with Shugan Jianpi Jiedu prescription combined with photodynamic therapy.The course of treatment was 3 months.Clinical efficacy,HPV viral load,positive to negative negative conversion rate,interferon-γ(IFN-γ),interleukin-2(IL-2),interleukin-10(IL-10),T lym-phocyte subsets,protein expression of MyD88 signaling pathway[interleukin-1 receptor-associated kinase-1(IRAK1),interleukin-1 receptor-associated kinase-4(IRAK4),tumor necrosis factor receptor-associated factor 6(TRAF6)],female sexual function index(FSFI),quality of life evaluation of condyloma acuminata(CECA10)score and recurrence at 3 months after follow-up were observed in the two groups.Results The total effective rate of observation group was 96.30%(52/54),which was higher than that of control group[81.48%(44/54)](P＜0.05).At 1 and 3 months after treatment,HPV viral load,serum IL-10 level and IRAK1,TRAF6 and IRAK4 expression levels in the observation group were lower than those in the control group,while the positive to negative conversion rate,CD3+,CD4+,CD4+/CD8+,serum IFN-γ and IL-2 lev-els,FSFI and CECA10 scores were higher than those of control group(P＜0.05).The recurrence rate of observation group was 9.26%(5/54),which was lower than that of control group[27.78%(15/54)](P＜0.05).Conclusion Shugan Jianpi Jiedu prescription assisted photodynamic therapy has significant efficacy in the treatment of condyloma acuminatum,which can reduce HPV viral load,increase positive to negative conversion rate,inhibit inflammatory response and protein ex-pression of MyD88 signaling pathway,regulate immune function,and block disease progression and recurrence.关键词
尖锐湿疣/光动力疗法/疏肝健脾解毒方/人乳头瘤病毒/干扰素-γ/白细胞介素-2/复发/病毒载量Key words
Condyloma acuminatum/Photodynamic therapy/Shugan Jianpi Jiedu prescription/Human papilloma-virus/Interferon-γ/Interleukin-2/Recurrence/Viral load分类
医药卫生引用本文复制引用
卢宁,李翠翠,高磊..疏肝健脾解毒方辅助光动力疗法对女性尖锐湿疣患者HPV病毒载量及免疫调节的作用[J].临床误诊误治,2024,37(6):95-100,6.基金项目
保定市科技计划项目(2341ZF230) （2341ZF230）
