西南医科大学学报2024，Vol.47Issue(3)：206-209,4.DOI:10.3969/j.issn.2096-3351.2024.03.005
子痫前期与甲状腺功能减退的双向因果关系:来自孟德尔随机化的遗传证据
Bidirectional Causality Between Preeclampsia and Hypothyroidism:Genetic Evidence from Mendelian Randomization
摘要
Abstract
Objective To analyze whether there is a causal association between pre-eclampsia and hypothyroidism by Mendelian randomization methods.Methods The pre-eclampsia and hypothyroidism data sets were obtained from the Finngen database,instru-mental variables were extracted,and five Mendelian randomization methods including the inverse variance weighting method were ap-plied to explore the causal association between pre-eclampsia and hypothyroidism.Sensitivity analyses such as Cochran's Q,MR-Egger regression,MR-PRESSO,and leave-one-out method were applied to evaluate the stability and reliability of the study results.Re-sults The results of the inverse variance weighting method showed that there was no causal association between pre-eclampsia and hypo-thyroidism(OR=1.024,95%CI:0.965-1.087,P=0.435),whereas there was a potentially positive causal association between hypothy-roidism and pre-eclampsia risk(OR=1.097,95%CI:1.006-1.196,P=0.036).The remaining four Mendelian randomization analyses showed a stable causal relationship between hypothyroidism and risk of preeclampsia.Cochrane's Q statistical results showed that there was no significant heterogeneity among the included instrumental variables.Neither the MR-Egger intercept method nor the MR-PRESSO method found significant horizontal pleiotropy among the included instrumental variables.However,leave-one-out results sug-gested that multiple instrumental variables played a decisive role in the causal association between hypothyroidism and risk of pre-eclampsia.Conclusions This study revealed the causal association between hypothyroidism and pre-eclampsia by applying the Mende-lian randomization method from the perspective of genetics,which provided a theoretical basis for the personalized management and treatment of people at high risk of pre-eclampsia.关键词
甲状腺功能减退/子痫前期/双向孟德尔随机化/因果关系Key words
Hypothyroidism/Pre-Eclampsia/Bidirectional Mendelian Randomization/Causality分类
医药卫生引用本文复制引用
张烨潇,王一枭,吴丹,周秀丽,乌兰..子痫前期与甲状腺功能减退的双向因果关系:来自孟德尔随机化的遗传证据[J].西南医科大学学报,2024,47(3):206-209,4.基金项目
国家自然科学基金(82101781) （82101781）
