西南医科大学学报2024，Vol.47Issue(3)：236-240,250,6.DOI:10.3969/j.issn.2096-3351.2024.03.011
白介素1β及白介素6基因单核苷酸多态性与食管癌放疗后肺部感染的关联
Association between gene single nucleotide polymorphisms of interleukin 1β and interleukin 6 and lung infection after radiotherapy for esophageal cancer
摘要
Abstract
Objective To analyze the association between human interleukin 1β(IL-1β)and interleukin 6(IL-6)gene single nucleotide polymorphisms and lung infection after radiotherapy for esophageal cancer,and to explore their physiological and pathologi-cal regulatory effects.Methods 115 patients with esophageal cancer treated in hospital between January 2019 and July 2022 were se-lected as the research subjects.According to whether lung infection occurred after radiotherapy,the patients were divided into lung in-fection group(n=28)and non-infection group(n=87).The single nucleotide polymorphisms(SNPs)at-511C/T(rs16944)and-31C/T(rs1143627)loci of IL-1β gene and at IL-6-572C/G(rs1800796)and IL-6-174G/C(rs1800795)loci of IL-6 gene were de-tected,and Spearman correlation test was used to analyze the relationship between gene polymorphisms of IL-1β and IL-6 and lung in-fection after radiotherapy for esophageal cancer.Multivariate Logistic regression analysis was performed to analyze the related factors of lung infection after radiotherapy for esophageal cancer.Results There were no statistically significant differences between the two groups of patients in terms of baseline data such as gender,age,BMI and clinical staging(P>0.05),and there were statistical differ-ences in radiotherapy time,tumor length and tumor location(P<0.05).The genotype distribution at rs16944 and rs1143627 loci of IL-1β gene and at rs1800796 and rs1800795 loci of IL-6 gene conformed to the Hardy-Weinberg genetic equilibrium law(P>0.05).The differences in the frequencies of CC,CT and TT genotypes and C and T alleles at rs16944 locus of IL-1β gene were not statistically sig-nificant between lung infection group and non-infection group(P>0.05),and the differences in frequencies of CC,CT and TT geno-types and C and T alleles at rs1143627 locus were statistically significant(P<0.05).There were statistical differences in the CC,CG and GG genotypes frequencies and C and G alleles frequencies at rs1800796 locus of IL-6 gene(P<0.05),and there were no statisti-cal differences in frequencies of CC,CG and GG genotypes and frequencies of C and G alleles at rs1800795 locus(P>0.05).Spear-man correlation test analysis showed that gene polymorphisms at rs1143627(C/T)locus of IL-1β and rs1800796(C/T)locus of IL-6 were significantly correlated with lung infection after radiotherapy for esophageal cancer(P<0.05).Multivariate Logistic regression analysis showed that radiotherapy time,tumor length、tumor location and single nucleotide polymorphisms at rs1143627 locus of IL-1β and rs1800796 locus of IL-6 were the multi-factors affecting lung infection in patients with esophageal cancer after radiotherapy(P<0.05).Conclusion IL-1β gene rs1143627(C/T)locus polymorphism and IL-6 gene rs1800796(C/G)locus polymorphism were re-lated to lung infection after radiotherapy for esophageal cancer,of which T allele at rs1143627 locus and G allele at rs1800796 locus might be the susceptible genes.关键词
白介素1β/白介素6/基因多态性/食管癌/放疗/肺部感染Key words
Interleukin 1β/Interleukin 6/Gene polymorphisms/Esophageal cancer/Radiotherapy/Lung infection分类
医药卫生引用本文复制引用
杨静,陈璐,刘燕子,祝金冉,王胜根..白介素1β及白介素6基因单核苷酸多态性与食管癌放疗后肺部感染的关联[J].西南医科大学学报,2024,47(3):236-240,250,6.基金项目
河南省医学科技攻关计划项目(LHGJ20190488) （LHGJ20190488）
