西南医科大学学报2024，Vol.47Issue(3)：246-250,5.DOI:10.3969/j.issn.2096-3351.2024.03.013
DCE-MRI定量参数与局部进展期宫颈癌患者临床病理特征及疗效的关系
Relationship between DCE-MRI quantitative parameters and clinicopathologi-cal characteristics and efficacy in patients with locally advanced cervical cancer
摘要
Abstract
Objective To explore the relationship between quantitative parameters of dynamic contrast-enhanced magnetic reso-nance imaging(DCE-MRI)and clinicopathological characteristics of locally advanced cervical cancer as well as efficacy of concurrent chemoradiotherapy.Methods 68 patients with locally advanced cervical cancer were selected between January 2017 and December 2020.All patients received DCE-MRI scan,and the relationship between quantitative parameters of DCE-MRI quantitative parameters[volume transfer constant(Ktrans),rate constant(Kep),extracellular space volume fraction(Ve)]and clinicopathological characteristics of patients with cervical cancer was analyzed.Patients with cervical cancer received concurrent chemoradiotherapy.The DCE-MRI quanti-tative parameters before treatment were compared between the effective group(n=39)and the ineffective group(n=29).Multivariate Logistic regression analysis was used to explore the influencing factors of efficacy.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of DCE-MRI quantitative parameters on efficacy of patients.Results Ktransin patients with squa-mous cell carcinoma was higher than that in patients with adenocarcinoma(P<0.05),and the Ktrans and Kep in lowly differentiated pa-tients were higher than those in medium-highly differentiated patients(P<0.05),and Ktrans,Kep and Ve in patients with clinical stage≥Ⅲa were higher than those in patients with stage<Ⅲa(P<0.05),but there were no statistically significant differences in DCE-MRI quantitative parameters of Ktrans,Kep and Ve among patients with different tumor diameters,presence or absence of lymph node metastasis or vascular invasion(P>0.05).The DCE-MRI quantitative parameters Ktrans,Kep,and Ve in effective group were higher than those in in-effective group before treatment(P<0.05).Multivariate Logistic regression analysis showed that clinical stage≥Ⅲa,Ktrans,Kep,and Ve were all risk factors affecting the efficacy of locally advanced cervical cancer(P<0.05).The areas under ROC curves of Ktrans,Kep,Ve and their combination on predicting the efficacy were 0.962,0.950,0.860 and 0.997 respectively.Conclusion Quantitative param-eters of DCE-MRI had a certain relationship with clinicopathological characteristics of patients with locally advanced cervical cancer,and could be used as predictors of efficacy of concurrent chemoradiotherapy.关键词
动态对比增强磁共振成像/宫颈癌/局部进展期/同步放化疗/预后Key words
Dynamic contrast-enhanced magnetic resonance imaging/Cervical cancer/Locally advanced/Concurrent chemo-radiotherapy/Prognosis分类
医药卫生引用本文复制引用
赵琳琳,李小潘,韩晓凤,徐文杰,宋园园..DCE-MRI定量参数与局部进展期宫颈癌患者临床病理特征及疗效的关系[J].西南医科大学学报,2024,47(3):246-250,5.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ202101266) （LHGJ202101266）
