西南医科大学学报2024，Vol.47Issue(3)：270-275,6.DOI:10.3969/j.issn.2096-3351.2024.03.018
LncRNA STEEL对内皮功能及表观调控血管生成的研究进展
Advances on lncRNA STEEL in vascular endothelial function and epigenetic regulation of angiogenesis
摘要
Abstract
Long non-coding RNA(lncRNA)is a functional RNA molecule with a length of more than 200 nucleotides and does not encode proteins.It is mainly involved in the regulation of gene expression at the transcriptional,post-transcriptional and epigenetic levels.Vascular endothelial cells are a single layer of flat cells that cover the surface of the blood artery lumen,providing a smooth inner surface for blood flow and ensuring appropriate blood circulation throughout the body.Some lncRNAs play an irreplaceable role in an-giogenesis by regulating the proliferation,migration,apoptosis and tube formation of endothelial cells to maintain specialized endothelial cell phenotypes and functions.The imbalance between lncRNA regulation and angiogenesis may lead to a variety of vascular diseases.Spliced transcript endothelial enriched lncRNA(STEEL)plays an important role in the epigenetic regulation of angiogenesis,thereby it has attracted much attention.This article reviewed the research progress of the effect of some endothelial-enriched lncrnas on endothe-lial function,especially lncRNA STEEL mediated angiogenesis in vascular endothelial cells through epigenetic regulation,which pro-vided a reference for the mechanism research and clinical application of angiogenesis.关键词
血管生成/内皮细胞/长链非编码RNA/表观遗传Key words
Angiogenesis/Endothelial cells/lncRNA/Epigenetic分类
医药卫生引用本文复制引用
胡绍润,杨沁之,李田,杨思祖,罗茂..LncRNA STEEL对内皮功能及表观调控血管生成的研究进展[J].西南医科大学学报,2024,47(3):270-275,6.基金项目
国家自然科学基金(82370419、81800434) （82370419、81800434）
四川省自然科学基金(2022NSFSC1601) （2022NSFSC1601）
四川省科技计划项目(2022YFS0627) （2022YFS0627）
四川省大学生创新创业训练计划项目(S202210632280) （S202210632280）
