间充质干细胞来源的外泌体miR-3614-5p通过抑制铁死亡改善模型大鼠先兆子痫进展的机制研究OACSTPCD
Mechanism Study of Mesenchymal Stem Cell Derived Exosome miR-3614-5p to Improve the Progression of Preeclampsia in Model Rats by Inhibiting Iron Death
目的 研究间充质干细胞来源外泌体微小核糖核酸-3614-5p(miR-3614-5p)对模型大鼠先兆子痫(preeclampsia,PE)进展的调节作用及相关机制.方法 将36只SD大鼠(24只雌性和12只雄性)以雌雄比例2∶1合笼饲养自然受孕.24只妊娠大鼠随机分为假手术组(sham组)、PE模型组(PE组)和外泌体miR-3614-5p组(PE+exo组),每组8只.PE组通过皮下注射100 mg/kg的NG-硝基-L-精氨酸甲酯建立大鼠PE…查看全部>>
Objective To investigate the regulatory effects of exosome microRNA-3614-5p(miR-3614-5p)derived from mesenchymal stem cells on the progression of preeclampsia(PE)in model rats and its related mechanisms.Methods Thirty-six SD rats(24 females and 12 males)were housed in cages at a female-to-male ratio of 2∶1 for natural conception.Twenty-four pregnant rats were randomly divided into sham group(sham group),PE model group(PE group)and exosome miR-3614-5p group(P…查看全部>>
李红;张丽云;房秋霞
唐山职业技术学院附属医院妇产科,河北唐山 063000唐山职业技术学院附属医院妇产科,河北唐山 063000唐山职业技术学院附属医院妇产科,河北唐山 063000
先兆子痫外泌体微小核糖核酸-3614-5p铁死亡
preeclampsiaexosomesmicroRNA-3614-5pferroptosis
《现代检验医学杂志》 2024 (3)
53-59,7
河北省卫生和计划生育委员会科研项目(编号20160880).
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