山东医药2024，Vol.64Issue(14)：36-39,4.DOI:10.3969/j.issn.1002-266X.2024.14.009
GLP-1受体激动剂利拉鲁肽皮下注射对肥胖雄性小鼠血清性激素水平的影响
Effects of subcutaneous injection of GLP-1 receptor agonist liraglutide on serum sex hormones in obese male mice
摘要
Abstract
Objective To investigate the effects of subcutaneous injection of glucagon-like peptide-1(GLP-1)re-ceptor agonist liraglutide on serum sex hormone levels in obese male mice.Methods Eighteen male C57BL/6J mice were randomly divided into the normal group(n=6),model group(n=6),and intervention group(n=6).Mice in the nor-mal group were fed with normal diet,and mice in the model group and intervention group were fed with high-fat diet to es-tablish the obesity models.After 10 weeks,mice in the intervention group were subcutaneously injected with liraglutide at 100 μg/(kg·d),and mice in the normal group and model group were subcutaneously injected with the equal volume of nor-mal saline for 12 weeks.Body weight was measured weekly.Fasting blood glucose(FBG)was measured using a blood glu-cose test strip.The serum levels of insulin(INS),luteinizing hormone(LH),follicle-stimulating hormone(FSH),testos-terone(T),free testosterone(FT),estradiol(E2),and sex hormone binding globulin(SHBG)were detected using ELI-SA.The homeostasis model assessment of insulin resistance(HOMA-IR)was calculated.Results Compared with the normal group,the body weight of the model group increased at 0,4,8,and 12 weeks(all P<0.01);compared with the model group,the body weight of the intervention group decreased at 4,8,and 12 weeks(all P<0.01);there was no statis-tically significant difference in body weight between the intervention group and the normal group at 12 weeks(P>0.05).After administration,compared with the normal group,the serum FBG,INS,and HOMA-IR levels increased in the model group(all P<0.01);compared with the model group,the serum FBG,INS,and HOMA-IR levels decreased in the inter-vention group(all P<0.01).Compared with the normal group,the levels of LH,FSH,T,and FT decreased and the lev-els of E2 and SHBG increased in the model group(all P<0.05);compared with the model group,the levels of LH,FSH,T,and FT in the intervention group increased,and the levels of E2 and SHBG decreased(all P<0.05).Conclusion The sex hormone levels of obese male mice are abnormal;liraglutide can improve the sex hormone levels of obese male mice,and its mechanism may be related to its significant effects of reducing blood glucose and body mass.关键词
胰高血糖素样肽1/利拉鲁肽/肥胖/性激素Key words
glucagon-like peptide-1/liraglutide/obesity/sex hormone分类
医药卫生引用本文复制引用
柒锐冰,蒋嘉钦,余劲明,吴兴烨,陈冰,李争明..GLP-1受体激动剂利拉鲁肽皮下注射对肥胖雄性小鼠血清性激素水平的影响[J].山东医药,2024,64(14):36-39,4.基金项目
广西自然科学基金面上项目(2020GXNSFAA297128). （2020GXNSFAA297128）
