上海海洋大学学报2024，Vol.33Issue(3)：543-551,9.DOI:10.12024/jsou.20240104411
3种不同海拔裂腹鱼肾脏转录组比较
Transcriptome comparative analysis of kidney tissues of three plateau Schizothoracinae fish species at different altitudes
摘要
Abstract
Subfamily has lived in the anoxic environment of Qinghai-Tibet Plateau for a long time,which is a natural biological model to study the adaptation mechanism of hypoxia.Transcriptome analysis was made on the kidneys of three species of Schizothorax curvilabiatus and Schizothorax macropogon at high altitude(＞3 600 m)and Schizothorax prenanti at low altitude(＜700 m).By comparing and analyzing the renal transcriptome of Schizothorax unicornis,Schizothorax megacephalus and Schizothorax homostoma,504 and 478 differentially expressing genes were screened out respectively,among which 199 genes were commonly differentially expressed.The enrichment analysis of common differential genes by GO(Gene Ontology)and KEGG(Kyoto encyclopedia of genes and genomes)showed that the two groups of common differential genes were mainly enriched in glycolysis/glycogen production,lipid biosynthesis,and angiogenesis.Among them,the high expression of eno3,fbp1α,prpf19,and ctsz may play an important role in the long-term adaptation of Schizothorax at high altitude to hypoxic environment.This study provides a new idea for revealing the long-term hypoxia adaptation of plateau fish.关键词
高原/裂腹鱼/转录组/糖代谢/低氧Key words
plateau/schizothoracine/transcription analysis/carbohydrate metabolism/hypoxia分类
农业科技引用本文复制引用
汤先湖,郝恬,江守文,吴智超,许强华..3种不同海拔裂腹鱼肾脏转录组比较[J].上海海洋大学学报,2024,33(3):543-551,9.基金项目
国家重点研发计划项目(2022YFD2400800,2018YFC0310600) （2022YFD2400800,2018YFC0310600）
国家自然科学基金面上项目(31772826) （31772826）
