外科理论与实践2024，Vol.29Issue(1)：40-45,6.DOI:10.16139/j.1007-9610.2024.01.07
意外胆囊癌病人预后列线图模型的构建
Construction of a prognostic Nomogram for patients with incidental gallbladder cancer
摘要
Abstract
Objective To construct and validate an effective prognostic nomogram for the patients with incidental gallbladder cancer(IGBC).Methods The clinical data of 161 patients with IGBC requiring radical surgery admitted to the First Affiliated Hospital of Xi'an Jiaotong University from May 2011 to October 2022 was analyzed retrospectively.COX proportional risk regression model was used to screen for influencing factors on overall survival(OS)of IGBC.Nomogram was constructed based on independent influencing factors that affected the prognosis of IGBC patients.The concordance index(C-index)and calibration curve were used to validate the performance of the model.Receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA)were used to validate the predictive accuracy and net benefit of the plotted column chart.Results Univariate COX regression analysis suggested that age,T stage,N stage,M stage,preoperative carcinoembryonic antigen(CEA),preoperative carbohydrate antigenl9-9(CA19-9),preoperative red blood cell volume distribution on width coefficient of variation(RDW-CV),treatment method,and recurrence and metastasis were risk factors which affected the long-term survival of IGBC patients after radical surgery.Multivariate COX regression analysis suggested that T stage,N stage,preoperative CA19-9,preoperative RDW-CV,preoperative AST,treatment methods,and recurrence and metastasis were independent risk factors which affected the prognosis of IGBC patients.The C-index of the constructed prognostic model was 0.872.The calibration plot demonstrated good performance of the Nomogram.ROC curve analysis showed an area under the curve of 0.869,confirming a high sensitivity and specificity.A high net benefit was proven by DCA.Conclusions The constructed Nomogram.can accurately and intuitively predict the survival probability of IGBC patients after radical surgery.关键词
意外胆囊癌/临床预测模型/预后分析/列线图Key words
Incidental gallbladder cancer/Clinical prediction model/Prognosis/Nomogram分类
医药卫生引用本文复制引用
莫建涛,曹瑞奇,任加强,耿智敏,仵正,程亚丽..意外胆囊癌病人预后列线图模型的构建[J].外科理论与实践,2024,29(1):40-45,6.基金项目
陕西省创新能力支撑计划(2022PT-35) （2022PT-35）
陕西省共性技术研发组建(2023GXJS-01-2) （2023GXJS-01-2）
西安交通大学第一附属医院临床研究课题(XJTU1AF-CRF-2022-034) （XJTU1AF-CRF-2022-034）
