现代检验医学杂志2024，Vol.39Issue(3)：37-41,114,6.DOI:10.3969/j.issn.1671-7414.2024.03.006
慢性心力衰竭患者血清miR-122和miR-558水平表达与心功能及心率变异性的相关性研究
Correlation between Serum miR-122 and miR-558 Levels and Cardiac Function and Heart Rate Variability in Patients with Chronic Heart Failure
林艳 1但汉良 1余扬 1高鹏 1黄继良 1白杨2
作者信息
- 1. 武汉市东西湖区人民医院心血管内科,武汉 430040
- 2. 华中科技大学同济医学院附属同济医院心血管内科,武汉 430030
- 折叠
摘要
Abstract
Objective To explore the relationship between serum microRNA(miR)-122 and microRNA(miR)-558 levels and cardiac function and heart rate variability in patients with chronic heart failure(CHF).Methods A total of 100 patients with chronic heart failure who were hospitalized in Wuhan Dongxihu District Poeple's Hospital from January 2019 to January 2022 were regarded as the study group,and 100 healthy individuals who underwent physical examinations in the hospital during the same period served as the control group.The real-time fluorescence quantitative PCR method was applied to detect the expressiou levels of serum miR-122 and miR-558 in two groups.The heart rate variability and cardiac function indicators of the two groups were compared.Pearson method was applied to analyze the correlation between serum miR-122 and miR-558 expression levels,and heart rate variability and cardiac function indicators in patients with chronic heart failure.Logistic regression was applied to analyze the risk factors affecting chronic heart failure.Results Compared with the control group,the serum miR-122(0.86±0.19 vs 1.07±0.16),heart rate variability indicators,and left ventricular ejection fraction(LVEF)of patients with chronic heart failure were decreased(t=3.844～15.448),and the expression level of miR-558(1.28±0.27 vs 1.02±0.12)and left ventricular end diastolic volume index(LVEDVI),left ventricular end systolic volume index(LVESVI)were increased(t=6.794～9.358),and the differences were statistically significant(all P＜0.05).The expression level of serum miR-122(1.19±0.23,1.04±0.21)in patients with functional grades Ⅰ to Ⅱ was higher than that in patients with grades Ⅲ to Ⅳ(0.68±0.16,0.53±0.15),while the expression level of miR-558(0.93±0.24,1.21±0.26)was lower than that in patients with grade Ⅲ-Ⅳ(1.42±0.27,1.64±0.29),with significant differences(qmiR-122=3.751～14.568,qmiR-558=3.929～11.194.all P＜0.05).The serum miR-122 level in patients with chronic heart failure was positively correlated with heart rate variability indicators and LVEF(r=0.337～0.573),but negatively correlated with LVEDVI and LVESVI(r=-0.385,-0.323).Serum miR-558 was negatively correlated with heart rate variability indicators and LVEF(r=-0.646～-0.246),but positively correlated with LVEDVI and LVESVI(r=0.528,0.547).Serum miR-122[OR(95％CI)=0.528(0.328～0.850)]and miR-558[OR(95％CI)=2.845(1.364～5.933)]were influencing factors for chronic heart failure(P＜0.05).Conclusion The expression levels of serum miR-122 and miR-558 in patients with chronic heart failure were closely related to heart rate variability and cardiac function,indicating that serum miR-122 and miR-558 may be influencing factors of chronic heart failure.关键词
慢性心力衰竭/微小RNA-122/微小RNA-558/心功能/心率变异性Key words
chronic heart failure/micro RNA-122/micro RNA-558/cardiac function/heart rate variability分类
医药卫生引用本文复制引用
林艳,但汉良,余扬,高鹏,黄继良,白杨..慢性心力衰竭患者血清miR-122和miR-558水平表达与心功能及心率变异性的相关性研究[J].现代检验医学杂志,2024,39(3):37-41,114,6.
