微创医学2024，Vol.19Issue(2)：139-143,5.DOI:10.11864/j.issn.1673.2024.02.07
宫颈上皮内瘤变合并高危型人乳头瘤病毒感染的临床特征
Clinical features of cervical intraepithelial neoplasia combined with high risk human papilloma virus infection
摘要
Abstract
Objective To investigate the clinical features of cervical intraepithelial neoplasia(CIN)combined with high risk human papilloma virus infection(HR-HPV).Methods A total of 150 patients with CIN combined with HR-HPV infection were selected as a study group,and 130 patients with negative HPV genotyping test results,smooth cervix without inflammation,and no other diseases or medical history were selected as a control group.All patients were tested for peripheral blood T lymphocyte subsets(including CD3+,CD4+,CD8+,CD4+/CD8+),inflammatory factors[interleukin-4(IL-4),interferon-y(IFN-γ)]levels and HPV DNA load.The levels of peripheral blood T lymphocyte subsets,HPV DNA load and distribution of patients with different CIN grades were compared between the two groups,and the correlation among CIN grade,HPV DNA load,T lymphocyte subsets and inflammatory factor level was analyzed.Results A total of 43 cases of CIN grade I,57 cases of CIN grade Ⅱ,and 50 cases of CIN grade Ⅲ were detected,as well as 32 cases of HPV DNA low load,41 cases of HPV DNA medium load,and 77 cases of HPV DNA high load.(1)The levels of CD3+,CD4+,CD4+/CD8+were lower and the level of CD8+was higher in the study group than those in the control group,with statistically significant differences(all P＜0.05).(2)With the increase of CIN grade,the HPV DNA load gradually increased,and the HPV DNA load level also changed(P＜0.05).(3)Patients'levels of CD3+,CD4+,CD4+/CD8+,IFN-γ and IL-2 decreased with the increase of CIN grade,while the levels of CD8+and IL-4 increased with the increase of CIN grade(P＜0.05).(4)With the increase of HPV DNA load,the levels of CD3+,CD4+,CD4+/CD8+,IL-2 and IFN-y decreased,while the levels of CD8+and IL-4 increased(P＜0.05).(5)CIN grade and HPV DNA load were negatively correlated with the levels of CD3+,CD4+,CD4+/CD8+,IL-2 and IFN-y,but positively correlated with CD8+and IL-4 levels(P＜0.05).Conclusion HR-HPV infection is the main risk factor for CIN,cervical cancer and other cervical lesions,in the process of HR-HPV infection,peripheral blood T lymphocyte subsets and inflammatory factors play an important role.关键词
宫颈上皮内瘤变/高危型人乳头瘤病毒/宫颈癌/感染/临床特征Key words
Cervical intraepithelial neoplasia/High risk human papilloma virus/Cervical cancer/Infection/Clinical feature引用本文复制引用
王慧芳,陈鲤,丘东海,苏晓娟,李丽红,李招娣..宫颈上皮内瘤变合并高危型人乳头瘤病毒感染的临床特征[J].微创医学,2024,19(2):139-143,5.基金项目
泉州医学高等专科学校科研项目(编号:XJK2111B) （编号:XJK2111B）
