中风与神经疾病杂志2024，Vol.41Issue(5)：408-412,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0079
北京地区帕金森病相关认知域评估量表的划界值研究
Cut-off values of cognitive domain assessment scales for Parkinson disease in Beijing,China
摘要
Abstract
Objective To establish the delimitation norm of cognitive domain assessment scales for Parkinson dis-ease(PD)in Beijing,China,and to investigate the optimal cut-off values for determining abnormal neuropsychological as-sessments.Methods A total of 33 normal middle-aged and elderly individuals in communities and 89 patients with non-dementia PD were included in this study,and all subjects underwent global cognitive function screening and cognitive do-main assessments.According to whether Montreal Cognitive Assessment(MoCA)score was greater than 25 points,the pa-tients with PD were divided into mild cognitive impairment group(PD-MCI group)and normal cognition group(PD-NC group).In order to compare the consistency between PD-related cognitive domain assessment scales and global cognitive function screening in the diagnosis of PD-MCI,different cut-off values below the appropriate norms(i.e.,1.00 standard deviation,1.28 standard deviations,1.64 standard deviations,1.96 standard deviations below the mean)were examined for sensitivity,specificity,positive predictive value,and negative predictive value to obtain the optimal cut-off value.Results The delimitation norm of PD-related cognitive domain assessment scales was established for Beijing,and the re-sults showed that 1.96 standard deviations had the highest consistency in the diagnosis of PD-MCI and PD-NC,with the best sensitivity and specificity.Conclusion This study establishes the delimitation norm of PD-related cognitive domain assess-ment scales and fills the blank of the unbounded value of most domestic PD cognitive impairment assessment scales,and it also proposes the optimal cut-off value of abnormal neuropsychological assessment,which provides a reference standard for the cognitive domain assessment of PD patients in China and helps clinicians to identify cognitive decline in PD patients and adopt intervention measures in the early stage.关键词
帕金森病/轻度认知障碍/常模/神经心理测评Key words
Parkinson disease/Mild cognitive impairment/Norm/Neuropsychological assessment分类
医药卫生引用本文复制引用
吴志悦,许二赫,薛晓帆,黄安琪,安静,刘国臻,张丽娟,许保磊,冯焕焕,陈彪..北京地区帕金森病相关认知域评估量表的划界值研究[J].中风与神经疾病杂志,2024,41(5):408-412,5.基金项目
国家重点研发计划(2021YFC2501200) （2021YFC2501200）
