中风与神经疾病杂志2024，Vol.41Issue(5)：470-475,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0090
利钠肽、cGMP与急性缺血性脑卒中的相关研究进展
Research advances in the association of natriuretic peptides and cyclic guanosine monophosphate with acute isch-emic stroke
摘要
Abstract
Natriuretic peptides(NPs)are closely associated with acute ischemic stroke(AIS),and previous studies have shown that NPs have the beneficial effects of promoting vasodilation and inhibiting inflammation and apoptosis.The beneficial cardiovascular effects of atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are associated with the natriuretic peptide receptor A/cyclic guanosine monophosphate(cGMP)signaling pathway.With the discovery of C-type natriuretic peptide(CNP)and its dependent receptor natriuretic peptide receptor B in brain tissue,NPs provide new ideas for the diagnosis and treatment of AIS.Recent studies have confirmed the beneficial effects of ANP,BNP,CNP,and their homologous receptors on neuronal damage induced by AIS;however,the specific mechanism of pathways mediated by NPs remains unknown.This article summarizes the studies on NPs,cGMP,and AIS,in order to provide a ref-erence for subsequent studies on NPs in AIS.关键词
利钠肽/急性脑缺血/cGMPKey words
Natriuretic peptides/Acute ischemic stroke/Cyclic guanosine monophosphate分类
医药卫生引用本文复制引用
李家任,刘嘉禹,张佳乐,石瑞丽,郝肖琼..利钠肽、cGMP与急性缺血性脑卒中的相关研究进展[J].中风与神经疾病杂志,2024,41(5):470-475,6.基金项目
国家自然科学基金项目(81960734) （81960734）
包头医学院博士科研启动基金(BSJJ201806) （BSJJ201806）
包头医学院科学研究基金项目(BYJJ-QM201905) （BYJJ-QM201905）
