中国临床药理学杂志2024，Vol.40Issue(9)：1292-1295,4.DOI:10.13699/j.cnki.1001-6821.2024.09.011
肉桂油对大鼠前列腺增生的治疗作用及其机制研究
Effect and mechanism of cinnamon oil on rat prostatic hyperplasia
摘要
Abstract
Objective To research the effect and the mechanism of cinnamon oil on experimental rat prostatic hyperplasia.Methods SD rats were randomly divided into normal group,model group,control group and cinnamon oil-H,-M,-L groups,with 10 rats in each group.The prostatic hyperplasia model was induced by injected subcutaneously with 5 mg·kg-1·d-1 testosterone propionate for 30 d.Normal group and model group were given 1 mL·kg-1 0.9％NaCl;control group were given 1 mg·kg-1 finasteride;cinnamon oil-H,-M,-L groups were given 1,0.5,0.25 mg·kg-1 cinnamon oil by intragastric administration,respectively,once a day for 30 d.The wet weight and index of prostate gland in rats were compared to explore the therapeutic effect of cinnamon oil,and the inhibitory effect of cinnamon oil on 5α-reductase and NADPH oxidase was studied to explore its mechanism.Results The prostate wet weight in normal group,model group,control group and cinnamon oil-H,-M,-L groups were(0.51±0.09),(1.02±0.17),(0.65±0.15),(0.64±0.17),(0.79±0.09)and(0.81±0.15)mg;the prostate index were(2.25±0.33),(4.70±0.48),(3.03±0.82),(3.02±0.60),(3.53±0.46)and(3.68±0.66)mg·kg-1;the fluorescence intensity of NADPH oxidase were(1.26±0.18),(5.21±0.80),(2.21±0.56),(2.51±0.56),(4.13±0.64)and(4.90±0.88)RLU,respectively.Compared with model group,the fluorescence intensity of NADPH oxidase in normal group,control group and cinnamon oil-H,-M groups all had significantly differences(all P＜0.01).The average inhibition rates of 5α-reductase in positive control group(20 μmol·L-1),cinnamon oil group(10,20 μmol·L-1)were 49.36％,45.62％and 63.45％,respectively.The average inhibition rate of 5α-reductase in cinnamon oil group(20 μmol·L-1)was higher than that in positive control group(20 μmol·L-1),the difference was statistically significant(P＜0.05).Conclusion Cinnamon oil may inhibit prostate hyperplasia by inhibiting 5α-reductase and NADPH oxidase.关键词
肉桂油/前列腺增生/5α-还原酶/还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶Key words
cinnamon oil/benign prostatic hyperplasia/5α-reductase/nicotinamide adenine dinucleotide phosphate oxidase分类
中医学引用本文复制引用
何微,宋蝶,王红萍,马松涛..肉桂油对大鼠前列腺增生的治疗作用及其机制研究[J].中国临床药理学杂志,2024,40(9):1292-1295,4.基金项目
成都医学院丽研工坊医美研究中心基金资助项目(22YM005) （22YM005）
四川省科技厅基金资助项目(2015GZX0077) （2015GZX0077）
