中国临床药理学杂志2024，Vol.40Issue(9)：1345-1349,5.DOI:10.13699/j.cnki.1001-6821.2024.09.022
基于人群特征的药源性心律失常自动监测模块优化及应用研究
Optimization and application of an automatic monitoring module for drug-induced arrhythmias based on population characteristics
摘要
Abstract
Objective To develop the functions and optimize the automatic monitoring module for arrhythmias of the adverse drug event active surveillance and assessment system-Ⅱ,in order to continuously improve the performance,enhance the monitoring efficiency,and explore the ways to optimize the module.Methods Expand and optimize the functions of the module,increase the customized configuration,and determine the optimal setting conditions;compare the optimized test data with the results of the evaluation studies on the automatic monitoring of drug-induced arrhythmias in large samples of medicated population previously,and verify the optimization extent as well as the accuracy of the module.Results In the new module optimized according to the characteristics of the monitoring population,the function of"mandatory medical order keywords"was added,and it was determined that the inclusion of 6 electrocardiogram examination-related medical order keywords with a frequency of not less than 2 occurrences was the optimal configuration condition for the optimization of the module;combining the results of the previous automatic monitoring and evaluation researches,the system functions were verified and compared under the conditions of using the whole drugs and 2 kinds of single drug.While there was no loss of true positive cases,the number of cases with system alarms decreased by 30.75％,80.13％and 90.82％,respectively,compared with that before the optimization of the module,and the positive predictive value was significantly improved.Conclusion After the function expansion and optimization,the automatic monitoring module of drug-induced arrhythmias significantly reduces the labor cost of case evaluation and keeps the accuracy of monitoring results constant;the new module can better adapt to the demands of different automatic monitoring modes and operates stably,which is more generalizable and flexible,and provides a new way of considering for the research and development of automatic monitoring modules.关键词
药源性心律失常/自动监测/模块优化/人群特征/药品不良反应/真实世界研究Key words
drug-induced arrhythmias/automatic monitoring/module optimization/population characteristics/adverse drug reactions/real world study分类
医药卫生引用本文复制引用
李鹏,郭代红,朱曼,高奥,郭海丽,伏安,赵安琪,石廷永..基于人群特征的药源性心律失常自动监测模块优化及应用研究[J].中国临床药理学杂志,2024,40(9):1345-1349,5.基金项目
2017年医学创新工程重点基金资助项目(17CXZ010) （17CXZ010）
中国研究型医院学会临床重点药品的使用监测和评价研究专项基金资助项目(Y2022FH-YWPJ03) （Y2022FH-YWPJ03）
