中国药房2024，Vol.35Issue(10)：1271-1275,5.DOI:10.6039/j.issn.1001-0408.2024.10.21
1例EGFR-TKI致间质性肺病合并艾滋病机会性感染肿瘤患者的药学服务
Pharmaceutical care for a case of tumor patient with interstitial lung disease due to EGFR-TKI and AIDS opportunistic infection
摘要
Abstract
OBJECTIVE To provide a reference for drug treatment and pharmaceutical care in AIDS patients with tumor.METHODS For a case of AIDS complicated with pulmonary adenocarcinoma,interstitial lung disease occurred repeatedly in the course of targeted therapy,and bacterial and fungal infections could not be ruled out.Clinical pharmacists provided pharmaceutical care such as medication monitoring,drug reconciliation,and adverse reaction monitoring for the patient.RESULTS The patient's use of Amivantamab is"highly likely related"to adverse reactions such as interstitial lung disease,and it is recommended by the clinical pharmacist that the targeted therapy drugs should be suspended,and hormone medication monitoring plans should be formulated.For the possible pathogens of AIDS opportunistic infection,it was recommended to stop ertapenem and foscarnet sodium,monitor voriconazole concentration in blood and follow up on the safety and antifungal course of voriconazole.According to the drug-drug interaction and the patient's condition,the anti-AIDS drug was adjusted to bictegravir sodium,emtricitabine and tenofovir alafenamide.For the possibility of Pneumocystis carinii pneumonia,thrombosis and gastric mucosal injury,preventive drugs such as Compound sulfamethoxazole,nadroparin calcium and esomeprazole were recommended.Physicians followed the advice of the clinical pharmacists.The patient made a good outcome after drug treatment without any significant adverse reactions or drug-drug interactions,and was discharged smoothly.CONCLUSIONS AIDS patients with tumor have complex disease condition and use many therapeutic drugs.Clinical pharmacists should conduct drug treatment management as drug reconciliation and medication monitoring and provide individual pharmaceutical care for these patients to guarantee the safety of drug use.关键词
艾滋病机会性感染/间质性肺病/肺腺癌/表皮生长因子受体-酪氨酸激酶抑制剂/药物重整/药物相互作用/药学监护Key words
AIDS opportunistic infection/interstitial lung disease/pulmonary adenocarcinoma/EGFR-TKI/drug reconciliation/drug-drug interaction/pharmaceutical care分类
医药卫生引用本文复制引用
冉拓耀,李超..1例EGFR-TKI致间质性肺病合并艾滋病机会性感染肿瘤患者的药学服务[J].中国药房,2024,35(10):1271-1275,5.基金项目
重庆市科卫联合医学科研项目(No.2023QNXM041) （No.2023QNXM041）
