复合因素诱导射血分数保留心力衰竭大鼠模型的建立及评价OA北大核心CSTPCD
Establishment and evaluation of a rat model of heart failure with a preserved ejection fraction induced by combined factors
目的 通过复合因素建立射血分数保留心力衰竭(HFpEF)大鼠模型,评估其特征,并探讨心肌应变参数与心肌肥厚及纤维化的相关性.方法 8 只WKY大鼠和 8 只自发性高血压大鼠(SHR)作为对照组,给予普通饲料至实验结束.32 只SHR大鼠平均分SHR+S组、SHR+F组、SHR+SF组及SHR+复合组,分别给予高盐饲料、高脂饲料、高盐-脂饲料、高盐-脂-糖饲料联合腹腔注射链脲霉素 30 周.造模结束后,测量心重/体重(HW/BW)、收缩压(SBP)…查看全部>>
Objective To evaluate the characteristics of a rat model of heart failure with a preserved ejection fraction(HFpEF)induced by combined factors,and to investigate the correlation of myocardial strain parameters to myocardial hypertrophy and fibrosis.Methods Eight WKY rats and eight spontaneously hypertensive rats(SHR)served as control groups and were fed normal feed until the end of the experiment.Thirty-two SHR rats were equally divided into SHR+S,SHR+F,SHR+…查看全部>>
石玉姣;杨晨光;乔文博;刘永成;刘思雨;董国菊
中国中医科学院西苑医院心血管内科,北京 100091中国中医科学院西苑医院心血管内科,北京 100091中国中医科学院西苑医院心血管内科,北京 100091中国中医科学院西苑医院心血管内科,北京 100091中国中医科学院西苑医院心血管内科,北京 100091中国中医科学院西苑医院心血管内科,北京 100091||国家中医心血管病临床医学研究中心,北京 100091
生物学
射血分数保留心力衰竭大鼠心肌应变心肌肥厚心肌纤维化
heart failure with preserved ejection fractionratmyocardial strainmyocardial hypertrophymyocardial fibrosis
《中国实验动物学报》 2024 (3)
275-285,11
国家自然科学基金面上项目(82074423),中国中医科学院科技创新重大攻关项目(CI2021A00903). Funded by the National Natural Science Foundation of China(82074423),the Major Innovation Project of the China Academy of Traditional Chinese Medicine(CI2021A00903).
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