抗阻运动对SAMP8小鼠骨骼肌lncRNA和mRNA基因表达谱的影响OA北大核心CSTPCD
Effects of resistance exercise on long non-coding RNA and mRNA expression profiles of skeletal muscle in senescence accelerated-prone 8 mice
目的 利用RNA-seq技术比较运动组与对照组小鼠股四头肌中差异表达的lncRNA和mRNA,探讨抗阻运动作用于SAMP8 小鼠的潜在调控机制.方法 12 只 28 周龄雄性SAMP8 快速衰老小鼠分为模型组(M组)、抗阻运动组(R组),每组 6 只;另设 6 只同龄SAMR1 抗衰老小鼠作对照组(C组).R组经递增负重爬梯运动训练 8 周.每 1 周测定相对抓力、每 2 周测转棒测试时间.取材后取右侧股四头肌进行苏木素-伊红(HE)染色观察其组…查看全部>>
Objective To explore the potential regulatory mechanism of resistance exercise in senescence accelerated-prone 8 mice(SAMP8)by evaluating the effects of exercise on the expression of long non-coding RNA(lncRNA)and mRNA in quadriceps muscles by RNA-sequencing(RNA-seq)technology.Methods Twenty-eight-week-old male SAMP8 mice were divided into a model group(M group)and resistance-exercise group(R group)(n=6 mice per group).Another eight normally aging SAMR1 mice…查看全部>>
傅泽铤;李仲豪;李伦宇;刘洪政;丁海丽
成都体育学院运动医学与健康研究所,成都 610041成都体育学院运动医学与健康研究所,成都 610041成都体育学院运动医学与健康研究所,成都 610041贵阳市白云区第三中学,贵阳 550014成都体育学院运动医学与健康研究所,成都 610041
生物学
长非编码RNASAMP8肌少症转录组抗阻运动
long non-coding RNASAMP8sarcopeniatranscriptomeresistance exercise
《中国实验动物学报》 2024 (3)
286-296,11
国家自然科学基金(81904318),四川省自然科学基金(2023NSFSC0545),四川省中央引导地方科技发展项目(2022ZYD0062),国家体育总局运动医学重点实验室(2018YFF0300904),运动医学四川省重点实验室(2021-A030),四川省科技创新创业苗子工程项目(2023JDRC0100). Funded by the National Natural Science Foundation of China(81904318),Sichuan Natural Science Foundation(2023NSFSC0545),Sichuan Province Central Government Guides Local Science and Technology Development Project(2022ZYD0062),the Key Laboratory of Sports Medicine of the General Administration of Sport of China(2018YFF0300904),Key Laboratory of Sports Medicine of Sichuan Province(2021-A030),Sichuan Province Science and Technology Innovation and Entrepreneurship Seedling Project(2023JDRC0100).
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