金雀异黄酮通过Toll样受体4信号通路改善急性心肌梗死大鼠左心室功能的研究OACSTPCD
Improvement of left ventricular function in rats with acute myocardial infarction through Toll-like receptor 4 signaling pathway by genistein
目的 基于Toll样受体 4(TLR4)信号通路探讨金雀异黄酮(GEN)对急性心肌梗死(AMI)大鼠左心室功能的影响及潜在机制.方法 100 只雄性SD大鼠随机分为假手术组、模型组、GEN(GEN,40 mg/kg)组、GEN+TAK242(TLR4 抑制剂,10 mg/kg)组和GEN+LPS(TLR4激动剂,5 mg/kg)组,每组 20 只.采用结扎冠状动脉左前降支的方法构建AMI大鼠模型,经1 次/d给药治疗 4 周后,通过心脏超声检测大…查看全部>>
Objective To explore the effect and potential mechanism of genistein(GEN)on left ventricular function in rats with acute myocardial infarction(AMI)based on Toll-like receptor 4(TLR4)signaling pathway.Methods One hundred male SD rats were randomly divided into sham operation group,model group,GEN(40 mg/kg)group,GEN+TAK242(TLR4 inhibitor,10 mg/kg)group,and GEN+LPS(TLR4 activator,5 mg/kg)group,with 20 rats in each group.The AMI rat model was established by liga…查看全部>>
姚飞;郭云亢;张丽娜
056001 邯郸,邯郸邯钢医院超声科056001 邯郸,邯郸邯钢医院超声科056000 河北省邯郸市中心医院心内三科
急性心肌梗死金雀异黄酮TLR4信号通路炎症细胞外基质
Acute myocardial infarctionGenisteinToll-like receptor 4 signaling pathwayInflammationExtracellular matrix
《心脑血管病防治》 2024 (3)
5-10,63,封3,8
河北省医学科学研究课题(20210854)
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